Assessment of Serum Interleukin-1β and Interleukin-6 Levels in Patients with Chronic Periodontitis and Coronary Heart Disease

Q4 Dentistry

European Journal of General Dentistry Pub Date : 2021-05-01 DOI:10.1055/s-0041-1732954

Firas B Al-Taweel, S. Saliem, O. Abd, S. Whawell

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引用次数: 5

Abstract

Abstract Objective The aim of this study was to assess whether serum cytokine levels correlate with clinical periodontal parameters in health or disease. Materials and Methods Male subjects (40–60 years) with CP (n = 30), CP + CHD (n = 30), and healthy controls (n = 20) had plaque index (PLI), gingival index (GI), bleeding on probing, probing pocket depth (PPD), and clinical attachment level (CAL) evaluated. Serum IL-1β and IL-6 levels were quantified using enzyme-linked immunosorbent assay. Results PLI, GI, PPD, and CAL were significantly higher in patients with CP + CHD compared to those with CP. Serum levels of IL-1β and IL-6 were also significantly higher in CP + CHD compared to those with CP, with both groups also being significantly higher than controls. There was a strong correlation between IL-1β and PPD and CAL and between IL-6 and GI and CAL in the CP group and between IL-6 and GI and PPD in the CP + CHD group. Conclusion The results provide further evidence that periodontitis triggers systemic inflammation. Cytokine levels in patients with periodontitis may represent a useful screening tool to identify those at greater risk of cardiovascular events.

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慢性牙周炎和冠心病患者血清白细胞介素-1β和白细胞介蛋白-6水平的评估

摘要目的本研究旨在评估血清细胞因子水平是否与健康或疾病中的临床牙周参数相关。材料和方法男性受试者（40-60岁）患有慢性阻塞性心脏病（n=30）、慢性阻塞性冠状动脉综合征+冠心病（n=30）和健康对照组（n=20）评估斑块指数（PLI）、牙龈指数（GI）、探诊出血、探诊袋深度（PPD）和临床附着水平（CAL）。采用酶联免疫吸附法测定血清IL-1β和IL-6水平。结果CP+CAD患者的PLI、GI、PPD和CAL均显著高于CP患者。CP+CAD组血清IL-1β和IL-6水平也显著高于CP组，两组均显著高于对照组。在CP组中，IL-1β与PPD和CAL之间、IL-6与GI和CAL之间以及在CP+CAD组中，IL-6与GI与PPD之间存在强相关性。结论该结果为牙周炎引发全身炎症提供了进一步的证据。牙周炎患者的细胞因子水平可能是一种有用的筛查工具，用于识别心血管事件风险更大的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of General Dentistry Dentistry-Dentistry (all)

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： European Journal of General Dentistry (EJGD) is one of the leading open-access international dental journal within the field of Dentistry. The aim of EJGD is publishing novel and high-quality research papers, as well as to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. EJGD publishes articles on all disciplines of dentistry including the cariology, orthodontics, oral surgery, preventive dentistry, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research.Moreover, EJGD also publish the scientific researches evaluating the use of new biomaterials, new drugs and new methods for treatment of patients with different kinds of oral and maxillofacial diseases or defects, the diagnosis of oral and maxillofacial diseases with new methods, etc. Moreover, researches on the quality of life, psychological interventions, improving disease treatment outcomes, the prevention, diagnosis and management of cancer therapeutic complications, rehabilitation, palliative and end of life care, and support teamwork for cancer care and oral health care for old patients are also welcome. EJGD publishes research articles, case reports, reviews and comparison studies evaluating materials and methods in the all fields of related to dentistry.