In vitro Enzyme Inhibition and In vivo Anti-hyperuricemic Potential of Malic Acid: An Experimental Approach

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2022-07-04 DOI:10.1080/22311866.2022.2124192

V. Vijeesh, A. Vysakh, N. Jisha, M. Latha

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引用次数: 1

Abstract

Abstract The prevalence of hyperuricemia among adolescents in developed and developing countries is of great concern. Hyperuricemia is a metabolic disorder that intensifies the risk of serious illnesses such as gout, diabetes, cardiovascular, renal complications etc. This can be controlled through regulating the xanthine oxidase (XO) enzyme activity. Current XO inhibitors used for the treatment exert some severe side effects. Naturally derived molecules are better alternative to overcome these issues. Malic acid, a four-carbon dicarboxylic acid, is mostly present in plants and fruits and is utilised extensively in the diet, chemical, and pharmaceutical industries. The IC50 value obtained for malic acid was 3.81 ± 0.002 × 10 M and it is a good competitive inhibitor. An altered levels of various biological markers (renal, hepatic and haematological) were observed in potassium oxonate induced in vivo hyperuricemia model. When treated with malic acid (different doses of 25, 50 and 100 mg/kg bwt), altered levels of biological function markers retained close to their normal range. The current study revealed the anti-hyperuricemic potential of malic acid. GRAPHICAL ABSTRACT

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苹果酸的体外酶抑制和体内抗高尿酸血症的实验研究

摘要高尿酸血症在发达国家和发展中国家的青少年中的患病率备受关注。高尿酸血症是一种代谢紊乱，会增加患痛风、糖尿病、心血管、肾脏并发症等严重疾病的风险。这可以通过调节黄嘌呤氧化酶（XO）活性来控制。目前用于治疗的XO抑制剂会产生一些严重的副作用。天然衍生分子是克服这些问题的更好选择。苹果酸是一种四碳二羧酸，主要存在于植物和水果中，广泛用于饮食、化工和制药行业。苹果酸的IC50值为3.81±0.002×。在氧代酸钾诱导的体内高尿酸血症模型中观察到各种生物标志物（肾脏、肝脏和血液学）水平的改变。当用苹果酸（不同剂量的25、50和100毫克/公斤体重）处理时，生物功能标志物水平的改变保持在接近正常范围的水平。目前的研究揭示了苹果酸的抗高尿酸血症潜力。图形摘要

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

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0.00%

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