Roles of innate lymphoid cells in tumor immunity and their clinical significance

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-09-30 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.09.013

C. Chai, Xi Ma, Bang Xin, Yang-an Wen

引用次数: 0

Abstract

Innate lymphoid cells (ILCs) are a recently characterized family of immune cells that have critical roles in innate immunity, immune regulation, maintenance of tissue homeostasis, and tissue repair and remodeling. Besides the conventional innate lymphocytes including NK cells and lymphoid tissue-inducer cells, the ILC family can be categorized into three groups, ILC1s, ILC2s and ILC3s. These non-cytotoxic ILC subsets have been identified to confer a diverse array of functions in oncogenesis and metastasis, immune surveillance, and antitumor immunity. In this review, we summarized the emerging findings in recent years regarding the roles of ILCs in immuno-oncology, and highlighted their potentials in immunotherapeutic approaches to tumors. Key words: Innate lymphoid cell; Immuno-oncology; Immunomodulation

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先天性淋巴细胞在肿瘤免疫中的作用及其临床意义

先天性淋巴细胞（ILCs）是一个最近表征的免疫细胞家族，在先天免疫、免疫调节、维持组织稳态以及组织修复和重塑中发挥着关键作用。除了包括NK细胞和淋巴组织诱导细胞在内的传统先天淋巴细胞外，ILC家族可分为三组，ILC1、ILC2和ILC3。这些非细胞毒性ILC亚群已被鉴定为在肿瘤发生和转移、免疫监测和抗肿瘤免疫中具有多种功能。在这篇综述中，我们总结了近年来关于ILCs在免疫肿瘤学中作用的新发现，并强调了它们在肿瘤免疫治疗方法中的潜力。关键词：先天性淋巴细胞；免疫肿瘤学；免疫调节

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.