3,5-Dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)2]+ complexes: synthesis, supramolecular chemistry and anti-cancer activity

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-06-24 DOI:10.1007/s10847-021-01082-6

Hawraa S. Al-Buthabhak, Yu Yu, Alexandre Sobolev, Hani Al-Salami, Murray V. Baker

引用次数: 1

Abstract

The synthesis and spectroscopic and structural characterisation of new 3,5-dibromophenyl-functionalised imidazolium salts and their corresponding [Au(NHC)₂]⁺ complexes is reported. X-ray diffraction studies revealed intra- and intermolecular interactions involving the 3,5-dibromophenyl group, including Br…π interactions with imidazolyl and C₆ arene rings. Au-NHC complexes functionalised with 3,5-dibromophenyl substituents showed potent activity against OVCAR-8 (ovarian cancer) cells at low micromolar concentrations.

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3,5-二溴苯基功能化咪唑盐及其相应的[Au(NHC)2]+配合物:合成、超分子化学及抗癌活性

报道了新型3,5-二溴苯基功能化咪唑盐及其相应的[Au(NHC)2]+配合物的合成、光谱和结构表征。x射线衍射研究揭示了3,5-二溴苯基分子内和分子间的相互作用，包括溴π与咪唑和C6芳烃环的相互作用。以3,5-二溴苯取代基功能化的Au-NHC配合物在低微摩尔浓度下显示出对OVCAR-8(卵巢癌)细胞的有效活性。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science

CiteScore

4.10

自引率

8.70%

发文量

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.