Mitochondria as a Critical Target of COVID-19 Pathogenesis

Reactive oxygen species (Apex, N.C.) Pub Date : 2022-03-03 DOI:10.20455/ros.2022.n.807

E. Ros

{"title":"Mitochondria as a Critical Target of COVID-19 Pathogenesis","authors":"E. Ros","doi":"10.20455/ros.2022.n.807","DOIUrl":null,"url":null,"abstract":"Over the past two years, findings from several research studies published in highly influential journals pointed to a critical involvement of mitochondria in the pathophysiology of SARS-CoV2 infections. Among the most exciting findings are the involvement of (i) the “mitochondrial ROS–HIF-1α –glycolysis” axis, (ii) the “cGAS–STING” signaling, and (iii) the “mitochondrial apoptotic cell death” pathway.\n(First online: March 3, 2022)\nREFERENCES \n\nDanial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116(2):205–19. doi: https://dx.doi.org/10.1016/s0092-8674(04)00046-7\nZorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 2014; 94(3):909–50. doi: https://dx.doi.org/10.1152/physrev.00026.2013\nRos EO. Mitochondrial ROS take center stage in immune regulation. React Oxyg Species (Apex) 2021; 11:n9–n10. doi: https://dx.doi.org/10.20455/ros.2021.n.809\nWeinberg SE, Sena LA, Chandel NS. Mitochondria in the regulation of innate and adaptive immunity. Immunity 2015; 42(3):406–17. doi: https://dx.doi.org/10.1016/j.immuni.2015.02.002\nCodo AC, Davanzo GG, Monteiro LB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, et al. Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1alpha/glycolysis-dependent axis. Cell Metab 2020; 32(3):437–46 e5. doi: https://dx.doi.org/10.1016/j.cmet.2020.07.007\nDomizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, et al. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Nature 2022. doi: https://dx.doi.org/10.1038/s41586-022-04421-w\nSimpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, et al. Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 2022. doi: https://dx.doi.org/10.1016/j.immuni.2022.01.003\n","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive oxygen species (Apex, N.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20455/ros.2022.n.807","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Over the past two years, findings from several research studies published in highly influential journals pointed to a critical involvement of mitochondria in the pathophysiology of SARS-CoV2 infections. Among the most exciting findings are the involvement of (i) the “mitochondrial ROS–HIF-1α –glycolysis” axis, (ii) the “cGAS–STING” signaling, and (iii) the “mitochondrial apoptotic cell death” pathway. (First online: March 3, 2022) REFERENCES Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116(2):205–19. doi: https://dx.doi.org/10.1016/s0092-8674(04)00046-7 Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 2014; 94(3):909–50. doi: https://dx.doi.org/10.1152/physrev.00026.2013 Ros EO. Mitochondrial ROS take center stage in immune regulation. React Oxyg Species (Apex) 2021; 11:n9–n10. doi: https://dx.doi.org/10.20455/ros.2021.n.809 Weinberg SE, Sena LA, Chandel NS. Mitochondria in the regulation of innate and adaptive immunity. Immunity 2015; 42(3):406–17. doi: https://dx.doi.org/10.1016/j.immuni.2015.02.002 Codo AC, Davanzo GG, Monteiro LB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, et al. Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1alpha/glycolysis-dependent axis. Cell Metab 2020; 32(3):437–46 e5. doi: https://dx.doi.org/10.1016/j.cmet.2020.07.007 Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, et al. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Nature 2022. doi: https://dx.doi.org/10.1038/s41586-022-04421-w Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, et al. Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 2022. doi: https://dx.doi.org/10.1016/j.immuni.2022.01.003

查看原文本刊更多论文

线粒体是新冠肺炎发病机制的关键靶点

在过去的两年里，发表在极具影响力的期刊上的几项研究结果表明，线粒体在严重急性呼吸系统综合征冠状病毒2型感染的病理生理学中起着关键作用。最令人兴奋的发现包括（i）“线粒体ROS–HIF-1α-糖酵解”轴的参与，（ii）“cGAS–STING”信号传导，以及（iii）“线粒体凋亡细胞死亡”途径。（首次在线：2022年3月3日）参考文献Danial NN，Korsmeyer SJ。细胞死亡：关键控制点。Cell 2004；116（2）：205–19.doi:https://dx.doi.org/10.1016/s0092-8674（04）00046-7Zorov DB，Juhaszova M，Sollott SJ.线粒体活性氧（ROS）和ROS诱导的ROS释放。Physiol Rev 2014；94（3）：909–50.doi:https://dx.doi.org/10.1152/physrev.00026.2013RosEO。线粒体ROS在免疫调节中处于中心阶段。React Oxyg物种（Apex）2021；11:n9–n10。doi:https://dx.doi.org/10.20455/ros.2021.n.809WeinbergSE、Sena LA、Chandel NS。线粒体在先天免疫和适应性免疫的调节中。豁免2015；42（3）：406–17.doi:https://dx.doi.org/10.1016/j.immuni.2015.02.002CodoAC、Davanzo GG、Monteiro LB、de Souza GF、Muraro SP、Virgilio da Silva JV等。葡萄糖水平升高通过HIF-1α/糖酵解依赖轴有利于严重急性呼吸系统综合征冠状病毒2型感染和单核细胞反应。细胞代谢2020；32（3）:437–46 e5。doi：https://dx.doi.org/10.1016/j.cmet.2020.07.007DomizioJD、Gulen MF、Saidoune F、Thacker VV、Yatim A、Sharma K等。cGAS-STING途径驱动新冠肺炎中的I型IFN免疫病理学。自然2022。doi：https://dx.doi.org/10.1038/s41586-022-04421-wSimpsonDS，Pang J，Weir A，Kong IY，Fritsch M，Rashidi M等。干扰素γ通过胱天蛋白酶-8和线粒体细胞死亡途径启动巨噬细胞进行病原体配体诱导的杀伤。豁免2022。doi：https://dx.doi.org/10.1016/j.immuni.2022.01.003

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Reactive oxygen species (Apex, N.C.)

自引率

0.00%

发文量