Impact of sarcopenia on the risk of falls, osteoporosis, fractures, and all causes of death among elderly people: A Meta-analysis of prospective cohort studies

Q4 Nursing

中华临床营养杂志 Pub Date : 2018-10-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.05.008

Min Cui, Kang Yu, Chun-wei Li

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引用次数: 0

Abstract

Objective To explore the relationship between sarcopenia and the risks of falls, osteoporosis, fractures and all-cause mortality among elderly people. Methods This was a meta-analysis of prospective cohort studies. Databases of OVID/Medline, PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Chinese WanFang Database were searched systematically according to the inclusion and exclusion criteria.The literatures related to the relationship between sarcopenia and falls, osteoporosis, fractures and all-cause mortality among elderly people from January 1987 to June 2017 were identified.The quality of the literature was evaluated by the risk assessment tool Newcastle-Ottawa Scale recommended by the Cochrane. Meta-analysis was conducted by RevMan 5.3 and Stata 12.1 software. Results Totally 13 prospective cohort studies including 19 376 subjects and 3 190 outcome events were entered in meta-analysis. The relative risk (RR) for comprehensive adverse outcome events among subjects with sarcopenia was 1.64 times of non-sarcopenia subjects(95% CI=1.51-1.78, P<0.000 01), and the RRs for fall, osteoporosis, fractures and all-cause mortality were 1.60 (95% CI=1.42-1.81, P<0.000 01), 4.85 (95% CI=2.18-10.79, P=0.000 1), 1.59 (95% CI=1.40-1.80, P<0.000 01), 2.08 (95% CI=1.18-3.69, P=0.01) times of non-sarcopenia subjects respectively. Conclusion Sarcopenia increases the risk of falls, fractures, all-cause mortality and comprehensive adverse outcome significantly, suggesting that sarcopenia might be a predictor for adverse outcomes among elderly people. Key words: Sarcopenia; Falls; Osteoporosis; Fractures; Mortality

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少肌症对老年人跌倒、骨质疏松、骨折和所有死因风险的影响：前瞻性队列研究的Meta分析

目的探讨老年人少肌症与跌倒、骨质疏松、骨折及全因死亡率的关系。方法对前瞻性队列研究进行荟萃分析。根据纳入和排除标准，系统检索OVID/Medline、PubMed、EMBASE、Cochrane Library、中国知网（CNKI）和中国万方数据库。对1987年1月至2017年6月老年人少肌症与跌倒、骨质疏松、骨折和全因死亡率关系的相关文献进行了整理。文献质量通过Cochrane推荐的风险评估工具Newcastle Ottawa量表进行评估。使用RevMan 5.3和Stata 12.1软件进行荟萃分析。结果共纳入13项前瞻性队列研究，包括19376例受试者和3190例结果事件。少肌症受试者发生综合不良反应的相对风险（RR）是非少肌症患者的1.64倍（95%CI=1.51-1.78，P＜0.000 01），跌倒、骨质疏松、骨折和全因死亡率的RR分别为1.60（95%CI=1.42-1.81，P＜.000 01）、4.85（95%CI=2.18-17.79，P＝0.000 1）、1.59（95%CI=1.40-1.80，P＜0.001），2.08（95%CI=1.18-3.69，P=0.01）倍。结论少肌症可显著增加跌倒、骨折、全因死亡率和综合不良反应的风险，提示少肌症可能是老年人不良反应的预测因素。关键词：Sarcopenia；瀑布；骨质疏松症；骨折；死亡率

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.