Evaluation of the Relationship Between Equol Production and the Risk of Locomotive Syndrome in Very Elderly Women

Q4 Medicine

International Journal of Probiotics and Prebiotics Pub Date : 2023-02-05 DOI:10.37290/ijpp2641-7197.18:7-13

T. Koike, S. Yamamoto, T. Furui, C. Miyazaki, H. Ishikawa, K. Morishige

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引用次数: 0

Abstract

This study aimed to evaluate whether equol production status has an impact on the risk of locomotive syndrome in very elderly (≥85 years old) women. In this retrospective observational study, 116 very elderly women were recruited from those who lived in nursing homes for the elderly from June 2018 to November 2019. Equol production status was determined by measuring spot urine levels of equol, and risks of locomotive syndrome were evaluated by vulnerable fracture history and loco-check, a simple questionnaire comprising seven questions that can describe locomotive syndrome. Equol production (≥1 μmol/L in a spot urine sample) was found in 46 women (39.6%). Loss of equol production contributes to some lococheck items, which correlate with weakness of lower limb muscle strength (P < 0.05). In this study population, 57 women (49.1%) had previous vulnerable fractures. However, equol production status was not significantly related to the vulnerable fracture in this study population (P = 0.159). Equol production might contribute to the induction of locomotive syndrome, at least in part. However, equol deficiency as a mechanism of locomotive syndrome induction might not be the primary cause of a previous vulnerable fracture in very elderly women who live in nursing homes.

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高龄妇女马术生产与机车综合征风险关系的评估

本研究旨在评估雌马的生产状况是否对高龄（≥85岁）妇女患机车综合征的风险有影响。在这项回顾性观察性研究中，从2018年6月至2019年11月居住在养老院的116名高龄女性中招募。通过测量点尿中的雌马酚水平来确定雌马酚的产生状态，并通过易损骨折史和运动检查来评估机车综合征的风险，这是一份简单的问卷，包括七个问题，可以描述机车综合征。在46名女性（39.6%）中发现了雌马酚的产生（当场尿样中≥1μmol/L）。雌马酚产生的损失导致了一些运动检查项目，这些项目与下肢肌肉力量的减弱有关（P<0.05）。在本研究人群中，57名女性（49.1%）曾有过易发性骨折。然而，在本研究人群中，雌马酚的产生状态与易发性骨折没有显著相关性（P=0.159）。雌马酚产生可能导致机车综合征的诱发，至少在一定程度上是这样。然而，作为机车综合征诱发机制的雌马缺乏可能不是居住在疗养院的高龄妇女先前易发生骨折的主要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Probiotics and Prebiotics Nursing-Nutrition and Dietetics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： The International journal of Probiotics & Prebiotics publishes on online only in an open access format. This is a broad based international, interdisciplinary peer reviewed scientific journal for critical evaluation of research on prebiotics, probiotics and synbiotics. The major goal of this journal is to provide unbiased scientific data to students, researchers, healthcare providers, and the decision makers in the nutraceutical industry to help make informed choices about prebiotics, probiotics and synbiotics. To this end, the journal will publish original research articles and two types of review articles. First, we will publish a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, we will publish a critical evaluation of current human experimental data to help deliver products with medically proven use.