Positive Selection in Zinc Finger Protein Reveals Genetic Signatures of Adaptive Evolution in Undifferentiated Stem Cells during Evolution in Mammals

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Mahboob Ali, Palwasha Khan, Mahreen Mahmood, Jilong Han, G. Afzal, Iram Qadeer, S. Azmal, N. El-Mouhty, S. Mahmoud, Ibrahim Jafri, Muhammad Ali, Nighat Hashmi
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Abstract

Positive selection refers to the process by which certain genetic variations are more likely to be passed on to future generations because they confer some advantage in terms of survival or reproduction. Zinc finger proteins are a type of transcription factor that plays a role in regulating gene expression, particularly in undifferentiated stem cells. Suppose it has been found that certain zinc finger proteins show genetic signatures of positive selection in mammals. In that case, it suggests that these proteins may have played a role in adaptive evolution in undifferentiated stem cells. This could mean that the specific genetic changes in these zinc finger proteins gave an advantage to the organisms that possessed them, helping them survive and reproduce more effectively. These genetic changes may have allowed the organisms to adapt to changing environments or to develop new abilities, such as increased resistance to disease or faster growth. Undifferentiated stem cells that underwent adaptive evolution during the evolution of mammals can be identified genetically by the outcomes of positive selection on zinc finger proteins. Because of selection pressures like environmental shifts or the introduction of novel pathogens, it is plausible that some zinc finger proteins have experienced fast evolution. The emergence of novel activities or higher expression levels of these proteins as a result of this quick evolution may have given the creatures that possessed them a survival edge. Another possible outcome of positive selection in zinc finger proteins is the emergence of new genetic variations that allow for increased diversity and plasticity in stem cells. This increased diversity and plasticity could have allowed for more efficient adaptation to changing environments and could have played a role in the evolution of new organisms or new characteristics in existing organisms. Overall, the results of positive selection in zinc finger proteins can provide insight into how adaptive evolution occurred in undifferentiated stem cells during the evolution of mammals and how this evolution may have contributed to the development of new organisms and new characteristics and adaptations to changing environments.
锌指蛋白的阳性选择揭示了哺乳动物进化过程中未分化干细胞适应性进化的遗传特征
正选择是指某些基因变异更有可能传递给后代的过程,因为它们在生存或繁殖方面具有一定的优势。锌指蛋白是一种转录因子,在调节基因表达方面发挥作用,尤其是在未分化干细胞中。假设已经发现某些锌指蛋白在哺乳动物中显示出阳性选择的遗传特征。在这种情况下,这表明这些蛋白质可能在未分化干细胞的适应性进化中发挥了作用。这可能意味着,这些锌指蛋白的特定基因变化为拥有它们的生物体带来了优势,帮助它们更有效地生存和繁殖。这些基因变化可能使生物体能够适应不断变化的环境或发展新的能力,例如增强对疾病的抵抗力或更快地生长。在哺乳动物进化过程中经历适应性进化的未分化干细胞可以通过锌指蛋白的阳性选择结果进行遗传鉴定。由于环境变化或新病原体的引入等选择压力,一些锌指蛋白可能经历了快速进化。由于这种快速进化,这些蛋白质出现了新的活性或更高的表达水平,这可能给拥有它们的生物带来了生存优势。锌指蛋白阳性选择的另一个可能结果是出现了新的遗传变异,从而增加了干细胞的多样性和可塑性。这种增加的多样性和可塑性本可以更有效地适应不断变化的环境,并可能在新生物的进化或现有生物的新特征中发挥作用。总的来说,锌指蛋白的阳性选择结果可以深入了解哺乳动物进化过程中未分化干细胞的适应性进化是如何发生的,以及这种进化如何有助于新生物的发展、新特征和对不断变化的环境的适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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