Phytochemical constituents and pharmacological potential of Solanum khasianum C.B. Clarke., extracts: Special emphasis on its skin whitening, anti-diabetic, acetylcholinesterase and genotoxic activities

IF 1.6 Q3 URBAN STUDIES

TOWN PLANNING REVIEW Pub Date : 2021-06-01 DOI:10.30495/TPR.2021.1917249.1190

Roktim Gogoi, Neelav Sarma, S. K. Pandey, M. Lal

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引用次数: 6

Abstract

This study was designed to evaluate and compare the phytochemical constituents along with the bioactivities of Solanum khasianum C.B. Clarke. leaves (SKLME) and berries (SKBME) methanolic extracts. Alkaloids, flavonoids, saponins, steroids, terpenoids, phenols, oxalates and cardiac glycosides were present in SKLME and SKBME. Considerable amounts of phenolic and flavonoids were found in SKLME and SKBME. SKBME showed better antioxidant activity with an IC50 value of 20.68 μg/mL vs SKLME (38.30 μg/mL). SKBME and SKLME respectively showed anti-inflammatory activity with IC50 of 20.96 and 23.37 μg/mL. Apart from this, the present investigation also reports SKBME skin whitening ability, anti-diabetic potential and anti-cholinesterase activity with IC50 values of 33.97, 28.24, and 32.42 μg/mL, respectively. Furthermore, SKLME showed herbicidal property with a total germination rate of 9.06% at a concentration of 80 μg/mL. Bioactivity analysis revealed higher pharmacological importance of the SKBME than SKLME, as well.

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龙葵的植物化学成分和药理潜力。，提取物：特别强调其美白皮肤、抗糖尿病、乙酰胆碱酯酶和基因毒性活性

本研究旨在评估和比较茄的植物化学成分和生物活性。叶（SKLME）和浆果（SKBME）甲醇提取物。SKLME和SKBME中存在生物碱、黄酮类化合物、皂苷、类固醇、萜类化合物、酚类化合物、草酸盐和强心苷类化合物。在SKLME和SKBME中发现了大量的酚类和黄酮类化合物。与SKLME（38.30μg/mL）相比，SKBME表现出更好的抗氧化活性，IC50值为20.68μg/mL。SKBME和SKLME分别具有抗炎活性，IC50分别为20.96和23.37μg/mL。除此之外，本研究还报道了SKBME的皮肤美白能力、抗糖尿病潜力和抗胆碱酯酶活性，IC50值分别为33.97、28.24和32.42μg/mL。此外，SKLME在80μg/mL的浓度下表现出除草性能，总发芽率为9.06%。生物活性分析显示SKBME的药理学重要性也高于SKLME。

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来源期刊

TOWN PLANNING REVIEW URBAN STUDIES-

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： Town Planning Review has been one of the world"s leading journals of urban and regional planning since its foundation in 1910. With an extensive international readership, TPR is a well established urban and regional planning journal, providing a principal forum for communication between researchers and students, policy analysts and practitioners. To mark TPR’s centenary in 2010, it is proposed to publish a series of ‘Centenary Papers’ -- review papers that record and reflect on the state of the art in a range of topics in the general field of town and regional planning.