T cell exhaustion and chimeric antigen receptor T cell immunotherapy in leukemia

国际输血及血液学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.06.010

Congxiao Zhang

引用次数: 0

Abstract

T cell exhaustion is a state of T cell dysfunction arises during various chronic viral, bacterial, parasitic infections and neoplastic disease, characterized by the stepwise loss of T cell function or even absence of the cell. Chimeric antigen receptor T cell (CAR-T) immunotherapy achieves the effect of treating tumors by collecting functionally active T cells from patients and conferring their ability to recognize tumor antigen in a human leukocyte antigen (HLA)-independent manner, and it has been widely used in treating leukemia, lymphoma and several solid tumors. To some degrees, the success of CAR-T immunotherapy was determined by the quality of T cells. Therefore, T cell exhaustion is one of huge obstacles of CAR-T immunotherapy. To explore the impact of T cell exhaustion on leukemia treatment, and provide new ideas for the immunotherapy of leukemia, the authors discussed the characteristics of T cell exhaustion in leukemia and the progresses of CAR-T immunotherapy. Key words: T-lymphocytes; Leukemia; Immunotherapy, adoptive; Receptors, chimeric antigen; T cell exhaustion

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白血病患者T细胞耗竭与嵌合抗原受体T细胞免疫治疗

T细胞衰竭是在各种慢性病毒、细菌、寄生虫感染和肿瘤性疾病中出现的一种T细胞功能障碍状态，其特征是T细胞功能的逐步丧失甚至细胞缺失。嵌合抗原受体T细胞（CAR-T）免疫疗法通过从患者身上收集功能活性T细胞并赋予其以人类白细胞抗原（HLA）非依赖性方式识别肿瘤抗原的能力来达到治疗肿瘤的效果，已广泛用于治疗白血病、淋巴瘤和几种实体瘤。在某种程度上，CAR-T免疫疗法的成功与否取决于T细胞的质量。因此，T细胞耗竭是CAR-T免疫治疗的巨大障碍之一。为了探讨T细胞耗竭对白血病治疗的影响，为白血病的免疫治疗提供新的思路，作者讨论了白血病T细胞耗竭的特点和CAR-T免疫治疗的进展。关键词：T淋巴细胞；白血病；免疫疗法，过继；受体，嵌合抗原；T细胞耗竭

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.