Secondary Metabolites and their Biological Activities from Endophytic Fungal Strain Aspergillus terreus XJA8 Associated with Vernonia anthelmintica

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2022-09-03 DOI:10.1080/22311866.2022.2154265

Nigora Rustamova, K. Bobakulov, Niu Litao, R. Nuerxiati, A. Wali, W. Setzer, A. Yili

引用次数: 3

Abstract

Abstract Two isocoumarins (6-methoxymellein and 6-hydroxymellein), one pyrrole compound (minaline), one lactone derivative (butyrolactone II), five phenolic acids (phenylacetic, veratric (3,4-dimethoxybenzoic), 4-hydroxyphenylacetic, 4-hydroxybenzoic and protocatechuic acid), and two phenolic acid methyl esters ((2-hydroxyphenyl) acetic acid methyl ester and methyl 4-hydroxyphenylacetate), along with 1,3-bis(4-hydroxyphenyl) propan-2-one were isolated from the fungal strain Aspergillus terreus XJA8. The fungal strain was isolated from the root of the medicinal plant Vernonia anthelmintica for first time. All isolated secondary metabolites were evaluated for their antimicrobial activity and melanin synthesis in murine B16 cells. GRAPHICAL ABSTRACT

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与驱虫Veronia相关的内生真菌Aspergillus terreus XJA8的次生代谢产物及其生物活性

摘要两种异香豆素（6-甲氧基mellein和6-羟基mellein），一种吡咯化合物（minaline），一个内酯衍生物（丁内酯II），五种酚酸（苯乙酸、异三（3，4-二甲氧基苯甲酸）、4-羟基苯乙酸、4-羟基苯甲酸和原儿茶酸），以及两种酚酸甲酯（（2-羟基苯基）乙酸甲酯和4-羟基苯甲酸甲酯），与1，3-双（4-羟基苯基）丙-2-酮一起从真菌菌株Aspergillus terreus XJA8中分离。首次从药用植物驱虫斑蝥根中分离到该真菌菌株。评估所有分离的次级代谢产物在小鼠B16细胞中的抗菌活性和黑色素合成。图形摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

自引率

0.00%

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