Effects of Salvia Officinalis Extract on the Breast Cancer Cell Line

SciMedicine journal Pub Date : 2019-03-01 DOI:10.28991/SCIMEDJ-2019-0101-4

H. Zare

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引用次数: 32

Abstract

Background: Common sage (Salvia officinalis L., Lamiaceae) is an aromatic and medicinal plant well known for its antioxidant properties. This plant belongs to Lamiaceae family and has many pharmaceutical properties. Some in vivo studies have shown the biological antioxidant effects of sage. As a member of Salvia officinalis Labiatae, sage is also known as “Maryam flower” in Iran. Sage importance lies in its therapeutic potential. It has been exploited as an anti-spasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory agent in Iranian medicine. Objective: Studying the anticancer effects of the compounds in Salvia officinalis extracts, such as cineol and camphor. Methods: Cancer was induced by DMBA (dimethyl-benzantheracene) dissolved in sunflower oil for 4 weeks. The case group was treated with sage leaf hydroalcoholic extract for 4 weeks; while the controls received distilled water. Result: Angiogenesis is a key process in cancer spread and metastasis. The hydroalcoholic extract of garden sage halted angiogenesis in the breast cell line of both human and mouse models; the highest impact was observed in hexane extract. Findings indicated the therapeutic effects of garden sage (i.e. its in vitro anti-angiogenesis activity and anti-migratory properties). Conclusion: Saliva officinalis can potentially prevent breast cancer.

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丹参提取物对乳腺癌症细胞株的影响

背景：鼠尾草（Salvia officinalis L.，Lamiaceae）是一种芳香药用植物，以其抗氧化特性而闻名。这种植物属于Lamiaceae科，具有许多药用特性。一些体内研究表明，鼠尾草具有生物抗氧化作用。鼠尾草是唇形科鼠尾草的一员，在伊朗也被称为“玛丽亚姆花”。Sage的重要性在于其治疗潜力。在伊朗医学中，它被用作抗痉挛、收敛、镇静、抗高血糖和抗炎药。目的：研究鼠尾草提取物中桂皮酚、樟脑等化合物的抗癌作用。方法：将二甲基苯甲酸二甲酯（DMBA）溶于葵花油中诱导癌症4周。病例组用鼠尾草叶水醇提取物治疗4周；而对照组接受蒸馏水。结果：血管生成是癌症扩散和转移的关键过程。花园鼠尾草的水醇提取物抑制了人类和小鼠模型乳腺细胞系中的血管生成；在己烷提取物中观察到最高的影响。研究结果表明了花园鼠尾草的治疗作用（即其体外抗血管生成活性和抗迁移特性）。结论：柳具有预防癌症的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SciMedicine journal

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0.00%

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审稿时长

8 weeks