Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

Onco Pub Date : 2023-07-26 DOI:10.3390/onco3030012

C. Baxevanis, S. Stokidis, M. Goulielmaki, A. Gritzapis, S. Fortis

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Abstract

Background: Various studies have reported associations between frequencies of total peripheral blood lymphocytes and prostate cancer prognosis, but none so far has addressed the prognostic role of CD8+ T-lymphocyte subsets. Methods: A total of 43 prostate cancer patients with metastatic disease and 81 patients with non-metastatic disease were included in this study. Flow cytometry analyses were employed for determining the frequencies of peripheral CD8+ T-lymphocyte subsets. Results: Statistically significant lower levels of terminally differentiated effector (TEMRA) cells in patients with non-metastatic disease vs. patients with metastatic disease were observed. Central memory (CM) and effector memory (EM) CD8+ subsets, were found to be significantly higher in patients with non-metastatic disease vs. patients with metastatic disease. A similar profile was revealed when these CD8+ subsets were analyzed based on the patients’ Gleason scores, as well as by combined disease stage (i.e., non-metastatic vs. metastatic disease) and Gleason score. Conclusions: Peripheral blood-derived CD8+ T-lymphocyte memory subsets could function as biomarkers for the prognosis of PCa.

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癌症患者外周血CD8+T淋巴细胞亚群与预后的关系

背景：各种研究报道了总外周血淋巴细胞频率与前列腺癌症预后之间的关系，但迄今为止没有一项研究涉及CD8+T淋巴细胞亚群的预后作用。方法：对43例前列腺癌症转移性疾病和81例非转移性疾病患者进行研究。流式细胞术分析用于测定外周CD8+T淋巴细胞亚群的频率。结果：观察到非转移性疾病患者的终末分化效应细胞（TEMRA）水平比转移性疾病的患者显著降低。发现非转移性疾病患者的中枢记忆（CM）和效应记忆（EM）CD8+亚群显著高于转移性疾病的患者。当根据患者的Gleason评分以及综合疾病分期（即非转移性疾病与转移性疾病）和Gleason得分分析这些CD8+亚群时，发现了类似的情况。结论：外周血CD8+T淋巴细胞记忆亚群可作为PCa预后的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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