Force-based stiffness mapping for early detection of breast cancer

IF 1.1 4区工程技术 Q3 ENGINEERING, MULTIDISCIPLINARY

Inverse Problems in Science and Engineering Pub Date : 2021-04-07 DOI:10.1080/17415977.2021.1912036

L. Olson, R. Throne, Emily I. Rusnak, J. P. Gannon

引用次数: 5

Abstract

ABSTRACT Early detection of breast cancer will continue to be crucial in improving patient survival rates for the foreseeable future. Our long-term goal is to automate and refine the manual breast exam process using measured data on the breast surface in combination with formal inverse techniques to generate three-dimensional maps of the stiffness inside the breast tissue. In this paper, we report on computational techniques that use force measurements to create the stiffness map and validate the computational techniques experimentally with silicone tissue phantom experiments. We conducted 16 tests on tumour-free phantom samples and 16 tests on tumour-containing phantoms. Our stiffness mapping approach resulted in one false positive and a correct identification of the remaining 31/32 samples.

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基于强迫刚度映射的癌症早期检测

摘要在可预见的未来，癌症的早期检测将继续对提高患者生存率至关重要。我们的长期目标是使用乳房表面的测量数据，结合形式逆技术，自动化和改进手动乳房检查过程，以生成乳房组织内部硬度的三维图。在本文中，我们报告了使用力测量来创建刚度图的计算技术，并通过硅组织体模实验验证了计算技术。我们对无肿瘤体模样品进行了16次测试，对含肿瘤体模进行了16项测试。我们的刚度映射方法导致了一个假阳性，并正确识别了剩余的31/32个样本。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inverse Problems in Science and Engineering 工程技术-工程：综合

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Inverse Problems in Science and Engineering provides an international forum for the discussion of conceptual ideas and methods for the practical solution of applied inverse problems. The Journal aims to address the needs of practising engineers, mathematicians and researchers and to serve as a focal point for the quick communication of ideas. Papers must provide several non-trivial examples of practical applications. Multidisciplinary applied papers are particularly welcome. Topics include: -Shape design: determination of shape, size and location of domains (shape identification or optimization in acoustics, aerodynamics, electromagnets, etc; detection of voids and cracks). -Material properties: determination of physical properties of media. -Boundary values/initial values: identification of the proper boundary conditions and/or initial conditions (tomographic problems involving X-rays, ultrasonics, optics, thermal sources etc; determination of thermal, stress/strain, electromagnetic, fluid flow etc. boundary conditions on inaccessible boundaries; determination of initial chemical composition, etc.). -Forces and sources: determination of the unknown external forces or inputs acting on a domain (structural dynamic modification and reconstruction) and internal concentrated and distributed sources/sinks (sources of heat, noise, electromagnetic radiation, etc.). -Governing equations: inference of analytic forms of partial and/or integral equations governing the variation of measured field quantities.