Therapeutic strategies for nerve injuries: current findings and future perspectives. Are textile technologies a potential solution?

IF 1 4区 工程技术 Q3 MATERIALS SCIENCE, TEXTILES
CRISTIAN-VLADIMIR Vancea, Andreea GROSU-BULARDA, A. Crețu, F. Hodea, Khalid Al-Falah, A. Stoian, A. Chiotoroiu, C. Mihai, C. Hariga, I. Lascar, R. Teodoreanu
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Abstract

Peripheral nerve lesions represent debilitating conditions that determine sensitive, motor and associated psychosocial losses, deeply and severely affecting the quality of life. Despite adequate microsurgical repair, functional results are variable and often dissatisfying. This study aimed to analyse and discuss peripheral nerve lesion cases from our clinic, involving the upper limb, an anatomical segment with impactful functional importance. We followed the distribution of nerve lesions throughout a three-year period, describing the patients’ characteristics and the therapeutic protocols. Furthermore, we reviewed the relevant literature to identify potential therapeutic strategies that may help optimize functional results. In the presented clinical study, most of the patients benefited from direct microsurgical repair of the nerve injury. However, we had a series of cases of nerve defects that could not be approached with primary repair. When a nerve cannot be repaired by direct neurorrhaphy, there are different options for bridging the nerve gap, each with its indications and advantages. Autografts still represent the gold standard in treating nerve gaps, but other procedures, such as vascularized nerve grafting, nerve conduits, allografts and nerve transfers, can be successfully used in some cases. The current focus in the field is the development of nerve conduits. Textile technologies represent a promising field in creating nerve conduits, given the ease of the manufacturing process, the affordable production cost and good mechanical properties.
神经损伤的治疗策略:当前发现和未来展望。纺织技术是一种潜在的解决方案吗?
外周神经损伤是一种使人衰弱的疾病,决定了敏感的、运动的和相关的心理社会障碍,严重影响生活质量。尽管进行了充分的显微外科修复,但功能结果参差不齐,常常令人不满意。本研究旨在分析和讨论我们临床上的周围神经损伤病例,涉及上肢,一个具有重要影响功能的原子节段。我们跟踪了三年期间神经病变的分布,描述了患者的特征和治疗方案。此外,我们回顾了相关文献,以确定可能有助于优化功能结果的潜在治疗策略。在本临床研究中,大多数患者受益于神经损伤的直接显微外科修复。然而,我们有一系列神经缺损的病例,这些病例无法通过初级修复来解决。当神经不能通过直接神经缝合修复时,有不同的选择来桥接神经间隙,每种选择都有其适应症和优点。自体移植物仍然是治疗神经间隙的金标准,但其他程序,如血管化神经移植、神经导管、同种异体移植物和神经转移,在某些情况下也可以成功使用。目前该领域的焦点是神经导管的开发。鉴于制造过程简单、生产成本低廉和良好的机械性能,纺织技术是增加神经导管的一个很有前途的领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Industria Textila
Industria Textila 工程技术-材料科学:纺织
CiteScore
1.80
自引率
14.30%
发文量
81
审稿时长
3.5 months
期刊介绍: Industria Textila journal is addressed to university and research specialists, to companies active in the textiles and clothing sector and to the related sectors users of textile products with a technical purpose.
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