UroLift implants as surrogate fiducial markers for cone-beam CT-based prostate image-guided radiotherapy

IF 0.3 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Radiotherapy in Practice Pub Date : 2023-03-03 DOI:10.1017/S1460396923000092

Ahmed A. Al-Balushi, M. Cain, Phil Reynolds, P. Bridge

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引用次数: 0

Abstract

Abstract Introduction: UroLift implants are a novel treatment for the obstructive lower urinary tract symptoms arising from benign prostatic hyperplasia. This case study aimed to assess their effectiveness as fiducial marker (FM) surrogates in prostate image-guided radiotherapy (IGRT). Method: Cone-beam CT images from a patient receiving prostate radiation therapy underwent manual alignment using UroLift implants and also prostate soft-tissue matching by five experienced therapeutic radiographers. The match values of both methods were compared using Bland–Altman analysis. All five observers were also asked to score the ease of matching using both approaches. Results: The 95% mean level of agreement for the UroLift matches were within a 2-mm threshold in all dimensions. Comparison of UroLift and prostate matches had 95% limit of agreement values of −0·98 to 1·78, −0·58 to 0·49 and −1·83 to 1·04 mm in the vertical, longitudinal and lateral planes, respectively. All of the UroLift matches were rated as ‘very easy’ or ‘possible with little difficulty’ by the five observers. Conclusion: A small difference between the CBCT UroLift and CBCT prostate match was found. It has been shown that IGRT to the prostate with the aid of the UroLift system implants and CBCT is feasible and can eliminate the need for FM implants. Wider evaluation in a large cohort is recommended.

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UroLift植入物作为基于锥束CT的前列腺图像引导放射治疗的替代基准标记

摘要简介：UroLift植入物是治疗良性前列腺增生引起的阻塞性下尿路症状的一种新方法。本病例研究旨在评估它们作为基准标记物（FM）替代物在前列腺图像引导放疗（IGRT）中的有效性。方法：一名接受前列腺放射治疗的患者的锥束CT图像采用UroLift植入物进行手动对准，并由五名经验丰富的放射治疗技师进行前列腺软组织匹配。使用Bland–Altman分析比较了两种方法的匹配值。所有五名观察者还被要求对使用这两种方法进行匹配的容易程度进行评分。结果：UroLift匹配的95%平均一致性在所有维度上都在2mm的阈值内。UroLift和前列腺匹配的比较在垂直、纵向和横向平面上的一致性极限值分别为−0.98至1.78、−0.58至0.49和−1.83至1.04 mm。所有的UroLift比赛都被五名观察员评为“非常容易”或“可能很难”。结论：CBCT UroLift和CBCT前列腺匹配之间存在微小差异。研究表明，借助UroLift系统植入物和CBCT对前列腺进行IGRT是可行的，可以消除对FM植入物的需求。建议在大型队列中进行更广泛的评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radiotherapy in Practice RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Journal of Radiotherapy in Practice is a peer-reviewed journal covering all of the current modalities specific to clinical oncology and radiotherapy. The journal aims to publish research from a wide range of styles and encourage debate and the exchange of information and opinion from within the field of radiotherapy practice and clinical oncology. The journal also aims to encourage technical evaluations and case studies as well as equipment reviews that will be of interest to an international radiotherapy audience.