Delivery Mode Affects the Sympathetic Nervous System in Healthy Term Newborns

Acta Medica Martiniana Pub Date : 2023-08-01 DOI:10.2478/acm-2023-0010

M. Kozar, Z. Kuderava, N. Ferencova, Z. Visnovcova, M. Zibolen, I. Tonhajzerova

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引用次数: 0

Abstract

Abstract Background Spontaneous delivery represents an important way triggering the physiological mechanisms essential for a proper postnatal adaptation of a newborn. Autonomic nervous system (ANS) plays a crucial role in this process. There is insufficient data concerning the impact of different delivery mode on ANS in newborns. Therefore, we aimed to study the effect of delivery mode on sympathetic nervous system (SNS) in healthy term newborns measured by electrodermal activity (EDA). Material & Methods The study conducted 50 healthy full – term newborns divided into two groups: the spontaneous delivery group (SD, n=27) and the caesarean section group (CS, n=23). EDA parameters (SCL – tonic level of skin conductance; NS.SCRs – non – specific phasic responses of skin conductance) were evaluated during three measurements: 2nd (M1), 24th (M2), and 72nd (M3) hours of life. Results SCL significantly decreased during the first day of life (M1 vs. M2 – p < 0.001). The lowest NS.SCRs values were demonstrated in M1 in both groups with significant differences in CS group between measurements – M1 vs. M2 (p=0.001) and M1 vs. M3 (p=0.005). However, a significantly lower NS.SCRs was found in CS group (p=0.01) early after birth (M1). Conclusion Our findings revealed a reduced NS.SCRs indicating potential decreased „arousal“ in CS group – it seems that the attenuated „arousal“ could reflect the absence of physiological labor mechanisms as well as the effect of anesthesia leading to discrete early functional abnormalities in CS group. Further research is needed to validate these findings.

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分娩方式对健康足月新生儿交感神经系统的影响

摘要背景自然分娩是触发新生儿适当产后适应所必需的生理机制的一种重要方式。自主神经系统（ANS）在这一过程中起着至关重要的作用。关于不同分娩方式对新生儿ANS影响的数据不足。因此，我们旨在通过皮肤电活动（EDA）来研究分娩方式对健康足月新生儿交感神经系统（SNS）的影响。材料与方法对50例健康足月新生儿进行研究，分为自然分娩组（SD，n=27）和剖宫产组（CS，n=23）。EDA参数（SCL–皮肤电导的紧张水平；NS.SCR–皮肤电导非特异性时相反应）在生命的第2（M1）、第24（M2）和第72（M3）小时的三次测量中进行评估。结果SCL在出生第一天显著下降（M1与M2，p＜0.001）。两组中M1的NS.SCR值最低，CS组在M1与M2（p＝0.001）和M1与M3（p＝0.005）之间存在显著差异。然而，CS组出生后早期（M1）的NS.SCRs显著较低（p＝0.01）。结论我们的研究结果显示，CS组的NS.SCR降低，表明潜在的“觉醒”降低——似乎“觉醒”减弱可能反映了CS组缺乏生理分娩机制以及麻醉导致离散早期功能异常的影响。需要进一步的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Martiniana

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.