Plagranline A, a Novel β-carboline and the First Alkaloid Isolated from Platycodon grandiflorus

Abstract

: A novel β -carboline, namely Plagranline A ( 1 ), and a known alkaloid ( 2 ) were isolated from the roots of Platycodon grandiflorus . Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.