Expression of cytokine genes and receptors in white blood cells associated with divergent body weight gain in beef steers

Q1 Agricultural and Biological Sciences

Agri Gene Pub Date : 2017-12-01 DOI:10.1016/j.aggene.2017.09.005

Amanda K. Lindholm-Perry , Virginia M. Artegoitia , Jeremy R. Miles , Andrew P. Foote

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引用次数: 1

Abstract

Previous work examining the transcriptome of steer tissue samples from animals with divergent gain have shown a relationship with the expression of genes with functions in immune and inflammatory pathways. The process of mounting an immune or inflammatory response is energetically expensive and variation in cytokine responses may affect cattle production traits. In addition, a previous study has identified variation in the transcript abundance of numerous genes, including the cytokine gene IL6ST, in the circulating white blood cells of pigs associated with high and low residual feed intake (RFI) lines. The aim of this study was to determine whether changes in cytokine expression in the circulating white blood cells (WBC) could also be associated with body weight gain in beef steers. Crossbred steers (n = 12) with average feed intake (10.9 kg/d), but divergent body weight gain (Low = 1.92 kg/d; High = 2.25 kg/d), were selected for the study. The genes CCR3, IL9R, PF4, NAMPT and TNF were associated with gain (P ≤ 0.05); and CSF1, IL2RG, IL6ST, CCL3, and TNFSF13B displayed a trend towards association with gain (P < 0.1). The expression of cytokine genes in circulating WBCs may be useful indicators of production traits in cattle.

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白血细胞中细胞因子基因和受体的表达与肉牛体重增加有关

先前的研究工作检查了来自不同增益动物的牛组织样本的转录组，显示了与免疫和炎症途径中具有功能的基因表达的关系。产生免疫或炎症反应的过程消耗大量能量，细胞因子反应的变化可能影响牛的生产性状。此外，先前的一项研究已经确定了猪循环白细胞中与高和低残余采食量(RFI)系相关的许多基因转录丰度的变化，包括细胞因子基因IL6ST。本研究的目的是确定循环白细胞(WBC)中细胞因子表达的变化是否也与肉牛体重增加有关。杂交阉牛(n = 12)，平均采食量为10.9 kg/d，但增重差异较大(低= 1.92 kg/d;高= 2.25 kg/d)，进行研究。CCR3、IL9R、PF4、NAMPT、TNF基因与增重相关(P≤0.05);而CSF1、IL2RG、IL6ST、CCL3和TNFSF13B则表现出与增益相关的趋势(P <0.1)。细胞因子基因在循环白细胞中的表达可能是牛生产性状的有用指标。

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来源期刊

Agri Gene Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

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期刊介绍： Agri Gene publishes papers that focus on the regulation, expression, function and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms. Agri Gene strives to be a diverse journal and topics in multiple fields will be considered for publication so long as their main focus is on agriculturally important organisms (plants, animals, insects, or microorganisms). Although not limited to the following, some examples of potential topics include: Gene discovery and characterization. Genetic markers to guide traditional breeding. Genetic effects of transposable elements. Evolutionary genetics, molecular evolution, population genetics, and phylogenetics. Profiling of gene expression and genetic variation. Biotechnology and crop or livestock improvement. Genetic improvement of biological control microorganisms. Genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens. Transcription analysis of beneficial or pest insect developmental stages Agri Gene encourages submission of novel manuscripts that present a reasonable level of analysis, functional relevance and/or mechanistic insight. Agri Gene also welcomes papers that have predominantly a descriptive component but improve the essential basis of knowledge for subsequent functional studies, or which provide important confirmation of recently published discoveries provided that the information is new.