Clostridium botulinum type A-virulome-gut interactions: A systems biology insight

Q1 Medicine

Human Microbiome Journal Pub Date : 2018-04-01 DOI:10.1016/j.humic.2018.01.003

P. Chellapandi, A. Prisilla

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引用次数: 10

Abstract

Clostridium botulinum is a foodborne bacterium capable of producing a potent botulinum neurotoxin with seven serotypes (A–G). Type A strains are being a great concern for causing foodborne, infant and wound botulism in worldwide. Antibacterial resistance is a not a big problem for treating diseases caused by this organism, but antitoxin treatment available today has not been reverse the paralysis. C. botulinum strain Hall A Sanger is a clinically important strain studied intensively for its biochemical and molecular characteristics. Gene cluster for botulinum toxin is strain-specific in nature, which might have evolved independently of each other. Type A strains have a common mechanism for transcription and metabolic regulation of botulinum toxin. BotR is a known transcriptional regulator that controls the expression of botulinum toxin in type A strains in response to nutritional factors in the gut. Two-component system is a key regulator required for the full virulence of this bacterium underlying response to the host and environmental factors. Amino-acid induced germination and chitin catabolic systems are firmly established in this organism, performing the separate processes of toxin or virulence factor synthesis, sporulation and germination. Several virulence factors have recently been identified from this genome, but molecular function of them in the gut of humans is not yet to be known. Genome-scale models are being as an integrated knowledge base for detailed understanding of its host-microbe interactions during the intoxication process.

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A型肉毒杆菌-病毒组-肠道相互作用:系统生物学的见解

肉毒杆菌是一种食源性细菌，能够产生七种血清型(a - g)的强效肉毒杆菌神经毒素。A型肉毒杆菌在世界范围内引起食源性、婴儿和伤口肉毒杆菌中毒。对于治疗由这种有机体引起的疾病来说，抗菌素耐药性不是一个大问题，但目前可用的抗毒素治疗并没有逆转瘫痪。C.肉毒杆菌Hall A Sanger是一种因其生化和分子特性而被广泛研究的重要临床菌株。肉毒杆菌毒素的基因簇在本质上是菌株特异性的，它们可能是相互独立进化的。A型菌株具有共同的肉毒毒素转录和代谢调节机制。BotR是一种已知的转录调节因子，可控制a型菌株对肠道营养因子的肉毒杆菌毒素表达。双组分系统是该细菌对宿主和环境因素的潜在反应的全部毒力所需的关键调节器。氨基酸诱导萌发和几丁质分解代谢系统在这种生物中牢固地建立起来，执行毒素或毒力因子合成，孢子形成和萌发的单独过程。最近已经从这个基因组中确定了几个毒力因子，但它们在人类肠道中的分子功能尚不清楚。基因组规模模型被作为一个综合知识库，详细了解其宿主-微生物在中毒过程中的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

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期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.