Synthesis, characterization and biological activity studies of certain 1-((benzo[d]thiazol-2-yl) methyl)-4,5-dihydro-3-methyl-N-phenyl-1H-pyrazol-5-imine and 2-((5-aryl-1H-1,2,4-triazol-3-yl) methyl)benzo[d]thiazoles

Abstract

Abstract In this work, 1-((benzo[d]thiazol-2-yl)methyl)-4,5-dihydro-3-methyl-N-phenyl-1H-pyrazol-5-imine (3a-h) have been successfully synthesized from the condensation of 2-((Benzo[d]thiazol-2-1-((benzo[d]thiazol-2-yl)methyl)-3-methyl-1H-pyrazol-5(4H)-one (2) with different aromatic amines. On the other hand, in another protocol, cyclization of 2-(benzo[d]thiazol-2-yl) acetohydrazide (4) with different aromatic aldehydes afforded 2-((5-aryl-1H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazoles (5a-h). A perusal of the biological activity studies revealed that the derivatives having chlorine as substituent are more toxic to all six bacteria. Among the chloro group compounds, the compound which has methoxy group is more toxic.