Characteristics of nalbuphine and its application in pediatric anesthesia

Pengpeng Guo, Jun Wang
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引用次数: 0

Abstract

Nalbuphine hydrochloride is an agonist-antagonist opioid that has analgesic and sedative effects, which can be used in perioperative period of pediatric patient. Nalbuphine hydrochloride reverses the adverse effects of μ receptor agonist (e.g. nausea, vomiting, itching) without influencing its analgesic effects. Due to the ceiling effect, nalbuphine does not cause respiratory depression. Nalbuphine has a higher safety factor, which makes it one of the most commonly used analgesic in paediatric patients. The application of nalbuphine is more popular in the country, thus, the indications of using nalbuphine in pediatric anesthesia should be clearly defined. The pharmacological properties of nalbuphine, clinical application of pediatric anesthesia were summarized in this review. Key words: Nalbuphine; Pediatric anesthesia; Analgesia; Sedation; Application
纳布啡的特点及其在小儿麻醉中的应用
盐酸纳洛酮是一种具有镇痛、镇静作用的阿片类激动剂拮抗剂,可用于小儿围手术期。盐酸纳洛酮可逆转μ受体激动剂的不良反应(如恶心、呕吐、瘙痒),但不影响其镇痛作用。由于天花板效应,那布芬不会引起呼吸抑制。纳洛酮具有较高的安全系数,这使其成为儿科患者最常用的止痛药之一。纳布芬在国内的应用更为普遍,因此,应明确在儿科麻醉中使用纳布芬的适应症。本文综述了萘布芬的药理作用及在小儿麻醉中的临床应用。关键词:纳布芬;小儿麻醉;镇痛;镇静;应用程序
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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