Pancreatic Function Enzymes In Patients On Maintenance Hemodialysis In Cameroon

Abstract

End kidney is with hemodynamic, biochemical and physiological abnormalities of and reduced renal clearance of pancreatic enzymes. Objective Assess the pancreatic function enzymes in patients on maintenance hemodialysis in Cameroon. We conducted a hospital-based cross-sectional study from De-cember 2017 to May 2018 at the Yaounde University Teaching Hospital dialysis unit. We included all consenting adults patients who provided a written informed consent and has been on hemodialysis for more than three months with a native arterio-venous fistula. We excluded patients presenting signs and symptoms of pancreatitis and any conditions which can increase serum pancreatic enzymes. We collected demographic, clinical and laboratory (calcemia, phos-phoremia, parathormone, amylasemia and lipasemia) data. Para-metric, non-parametric and correlations tests were used to compare variables. Results We included 60 (68.3% males) participants with a mean (SD) age of 47.4 (15.8) years and duration in dialysis of 2.1 (0.6) years. Hypertension (30%), diabetes mellitus and chronic glomer- ulonephritis (23.3%) were the main baseline nephropathy. There were 7 (11.7%) overweight/obese. Hypercalcemia was noticed in 2 (3.3%) patients whereas hyperphosphatemia and increased parathormone levels were observed in 35 (58.3%) and 28 (46.7%) pa- tients respectively. The mean (SD) lipasemia and amylasemia was 130.6 (43.3) UI/L and 131.8 (62.5) UI/L respectively. Hyperlipase- mia and hyperamylasemiawereobservedin59 (98.3%) and 48 (80%) participants respectively. The lipasemia was three times above the upperlimitsin10 (24.4%) participants. Only lipasemia was positively and significantly correlated with amylasemia (r=0.5; p<0.001). We observed that almost all patients had hyperlipasemia with nearly a quarter having values above the cut-off point to diagnose acute pancreatitis and eight out of ten had hyperamylasemia. There was a positive correlation between lipasemia and amylasemia.