Nucleophosmin: from structure and function to disease development

IF 2.946 Q3 Biochemistry, Genetics and Molecular Biology

BMC Molecular Biology Pub Date : 2016-08-24 DOI:10.1186/s12867-016-0073-9

Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard

引用次数: 180

Abstract

Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.

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核蛋白:从结构、功能到疾病发展

核磷蛋白(nuclear ophosmin, NPM1)是一种重要的细胞蛋白，参与mRNA转运、染色质重塑、细胞凋亡和基因组稳定性等多种途径。NPM1功能是正常细胞生物学的关键要求，正如在癌症中强调的那样，NPM1通常过表达、突变、重排和偶尔缺失。与细胞内的多功能作用一致，NPM1不仅可以作为原癌基因，还可以作为肿瘤抑制基因。这篇综述的目的是研究NPM1在DNA修复途径中的作用，以及NPM1在癌症细胞凋亡及其突变的调节中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Molecular Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： BMC Molecular Biology is an open access journal publishing original peer-reviewed research articles in all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function.