Physicochemistry in medicine: some selected examples

Q3 Chemistry

Journal of Spectral Imaging Pub Date : 2019-09-05 DOI:10.1255/jsi.2019.a16

D. Bazin, M. Daudon

{"title":"Physicochemistry in medicine: some selected examples","authors":"D. Bazin, M. Daudon","doi":"10.1255/jsi.2019.a16","DOIUrl":null,"url":null,"abstract":"Research on pathological calcifications constitutes an exciting topic at the interface between physics, chemistry\nand medicine. The relationship between their physicochemical characteristics and the pathology responsible for their\nformation offers a unique opportunity to perform a significant medical diagnosis, to assess the interaction between drugs\nand these biological entities as well as to develop new drugs. Regarding synchrotron radiation, the emergence of\nmicrobeam allows the clinician to perform an early diagnosis. Indeed, we will start this review with a clinical case where\nFourier transform infrared spectroscopy using synchrotron radiation as a probe allowed the clinician to save the kidney\nfunction of a patient. Following this example, we will see that investigations on pathological calcifications constitute an\nelegant way to gather major information on different public health problems such type 2 diabetes as well as on rare\ndiseases. To attain this goal, this mini-review dedicated to structural and chemical investigations and based on selected\nand recent data collected through techniques using third generation synchrotron radiation as a probe is proposed to the\nreader.","PeriodicalId":37385,"journal":{"name":"Journal of Spectral Imaging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Spectral Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1255/jsi.2019.a16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}

引用次数: 4

Abstract

Research on pathological calcifications constitutes an exciting topic at the interface between physics, chemistry and medicine. The relationship between their physicochemical characteristics and the pathology responsible for their formation offers a unique opportunity to perform a significant medical diagnosis, to assess the interaction between drugs and these biological entities as well as to develop new drugs. Regarding synchrotron radiation, the emergence of microbeam allows the clinician to perform an early diagnosis. Indeed, we will start this review with a clinical case where Fourier transform infrared spectroscopy using synchrotron radiation as a probe allowed the clinician to save the kidney function of a patient. Following this example, we will see that investigations on pathological calcifications constitute an elegant way to gather major information on different public health problems such type 2 diabetes as well as on rare diseases. To attain this goal, this mini-review dedicated to structural and chemical investigations and based on selected and recent data collected through techniques using third generation synchrotron radiation as a probe is proposed to the reader.

查看原文本刊更多论文

医学中的物理化学：几个精选的例子

病理钙化的研究是物理学、化学和医学之间一个令人兴奋的话题。它们的物理化学特征和形成它们的病理学之间的关系为进行重要的医学诊断、评估药物和这些生物实体之间的相互作用以及开发新药提供了独特的机会。关于同步辐射，微束的出现使临床医生能够进行早期诊断。事实上，我们将从一个临床案例开始这篇综述，其中使用同步辐射作为探针的傅里叶变换红外光谱允许临床医生挽救患者的肾脏功能。在这个例子之后，我们将看到，对病理钙化的调查是收集不同公共卫生问题（如2型糖尿病和罕见病）主要信息的一种重要方式。为了实现这一目标，提出了这篇专门用于结构和化学研究的小型综述，并基于通过使用第三代同步加速器辐射作为探针的技术收集的选定和最新数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Spectral Imaging Chemistry-Analytical Chemistry

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： JSI—Journal of Spectral Imaging is the first journal to bring together current research from the diverse research areas of spectral, hyperspectral and chemical imaging as well as related areas such as remote sensing, chemometrics, data mining and data handling for spectral image data. We believe all those working in Spectral Imaging can benefit from the knowledge of others even in widely different fields. We welcome original research papers, letters, review articles, tutorial papers, short communications and technical notes.