Adverse Drug Reactions of Antiepileptic Drugs in the Neurology Department of a Tertiary Care Hospital, Srinagar, Jammu & Kashmir, India

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2021-04-30 DOI:10.5812/ANS.112364

Mudasir Maqbool, Dinka Dugassa, Ginenus Fekadu

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引用次数: 2

Abstract

Background: Epilepsy is a disorder that affects 1% of the global population. It is the second most common serious neurologic disorder after stroke, affecting humans. Since antiepileptic drugs have a narrow therapeutic index and their adverse effects can affect any organ, their widespread use has significant safety implications. Objectives: The study assessed adverse drug reactions (ADRs) using antiepileptic drugs in the Department of Neurology at a Tertiary Care Hospital, Srinagar, Jammu & Kashmir, India. Methods: This prospective observational study was conducted in the Department of Neurology of a Tertiary Care Hospital, Srinagar, Jammu & Kashmir, India, for eight months. It was a spontaneous reporting of ADRs by practicing physicians in the outpatient and inpatient settings that were included in the study. Results: Of the 3,300 patients who were on the anti-epileptic drug (AED), 92 (3.07%) had AED-related ADRs. A total of 18 cases were reported in the inpatient department and 74 cases in the outpatient setting. The most common ADRs were loss of appetite (34.78%), skin rashes (17.39%), and gum hypertrophy (9.78%). Of 80 ADRs, 42.5% were related to valproate, followed by phenytoin, carbamazepine, and levetiracetam. The suspected drug was changed in 22 patients with ADRs. Conclusions: For the early diagnosis and avoidance of ADRs, the frequent follow-up of patients on AEDs is needed to improve patient compliance with drug therapy and provide better drug therapy for avoiding associated morbidity and mortality.

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印度查谟和克什米尔斯利那加一家三级医院神经内科抗癫痫药物的不良反应

背景：癫痫是一种影响全球1%人口的疾病。它是仅次于中风的第二常见的严重神经系统疾病，影响人类。由于抗癫痫药物的治疗指标很窄，其不良反应可以影响任何器官，因此其广泛使用具有重要的安全性。目的：该研究评估了印度查谟和克什米尔斯利那加一家三级护理医院神经内科使用抗癫痫药物的不良反应（ADR）。方法：这项前瞻性观察性研究在印度查谟和克什米尔斯利那加一家三级护理医院的神经内科进行，为期八个月。这是纳入研究的门诊和住院环境中执业医生自发报告的ADR。结果：在3300例服用抗癫痫药物的患者中，92例（3.07%）出现了与抗癫痫药物相关的不良反应。住院部共报告18例，门诊部共报告74例。最常见的不良反应是食欲不振（34.78%）、皮疹（17.39%）和牙龈肥大（9.78%）。在80例不良反应中，42.5%与丙戊酸钠有关，其次是苯妥英、卡马西平和左乙拉西坦。22例ADR患者更换了可疑药物。结论：为了早期诊断和避免ADR，需要经常对患者进行AED随访，以提高患者对药物治疗的依从性，并为避免相关的发病率和死亡率提供更好的药物治疗。

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Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.