Systematic review of Mendelian randomization studies on Parkinson's disease.

IF 0.8 4区生物学 Q4 GENETICS & HEREDITY

Medizinische Genetik Pub Date : 2022-08-12 eCollection Date: 2022-06-01 DOI:10.1515/medgen-2022-2139

Sophia Kappen, Daniele Bottigliengo, Amke Caliebe, Fabiola Del Greco M, Inke R König

{"title":"Systematic review of Mendelian randomization studies on Parkinson's disease.","authors":"Sophia Kappen, Daniele Bottigliengo, Amke Caliebe, Fabiola Del Greco M, Inke R König","doi":"10.1515/medgen-2022-2139","DOIUrl":null,"url":null,"abstract":"Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves.Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence.Results: Twelve articles were included. Most studies showed \"good\" methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects.Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.","PeriodicalId":48632,"journal":{"name":"Medizinische Genetik","volume":"34 1","pages":"143-150"},"PeriodicalIF":0.8000,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006297/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medizinische Genetik","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/medgen-2022-2139","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Parkinson's disease (PD) is known to be associated with non-genetic factors. To infer causality, Mendelian randomization (MR) studies are increasingly used. Here, genetic variants are used as instrumental variables for the risk factor but have no direct effect on PD themselves.

Methods: We performed a systematic literature review on MR studies for PD. Studies were identified searching the PubMed database. Upon data extraction, we evaluated the methodological quality and summarized the evidence.

Results: Twelve articles were included. Most studies showed "good" methodological quality, but most did not report proper power estimations. Twelve analyses yielded nominally significant effects.

Conclusions: Our systematic review shows that most MR studies were well performed and allow to identify causal exposures, which may inform further studies on the prevention and early intervention of PD.

查看原文本刊更多论文

帕金森病孟德尔随机化研究的系统综述

摘要背景众所周知，帕金森病与非遗传因素有关。为了推断因果关系，孟德尔随机化（MR）研究越来越多地被使用。在这里，遗传变异被用作危险因素的工具变量，但对帕金森病本身没有直接影响。方法我们对帕金森病的MR研究进行了系统的文献综述。研究是在PubMed数据库中确定的。在数据提取后，我们评估了方法学质量并总结了证据。结果共收录文章12篇。大多数研究显示出“良好”的方法质量，但大多数研究没有报告适当的功率估计。12项分析产生了名义上显著的影响。结论我们的系统综述表明，大多数MR研究都进行得很好，可以确定因果暴露，这可能为进一步研究PD的预防和早期干预提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medizinische Genetik Medicine-Genetics (clinical)

CiteScore

1.40

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter. medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community. In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.