Hypercatecholaminaemia in stress urinary incontinence and its pathogenetic treatment perspectives: an experimental non-randomised study

Kubanskii nauchnyi meditsinskii vestnik Pub Date : 2022-05-01 DOI:10.25207/1608-6228-2022-29-2-118-130

A. Kade, D. N. Kazanchi, P. P. Polyakov, S. A. Zanin, P. A. Gavrikova, Z. Katani, K. M. Chernysh

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Abstract

Background. Urinary incontinence is associated with chronic psycho-emotional stress. Stress management should be part of a comprehensive treatment for urinary incontinence.Objectives. An assessment of hypercatecholaminaemia severity and dynamics in repeated courses of TES therapy for stress urinary incontinence.Methods. A total of 100 stress urinary incontinence patients were divided between a comparison and two main cohorts. Main cohort 1 (n = 30) received a modern standard treatment in combination with TES therapy. TES therapy was performed in three courses (1 session per day for 7 days): course 1 on admission, course 2 in 3 months after course 1, course 3 in 6 months after course 1. Main cohort 2 (n = 40) received a modern standard treatment in combination with two short courses of TES-therapy (2 sessions per day for 7 days): course 1 on admission, course 2 in 6 months after course 1. The comparison cohort (n = 30) only had standard treatment. Catecholamine concentrations were assessed over time in each cohort.Results. Catecholamine concentrations were >2 times higher before treatment in all cohorts vs. healthy volunteers. The comparison cohort revealed adrenaline and noradrenaline concentrations 71.2% (p < 0.05) and 84.0% (p < 0.05) higher vs. healthy volunteers, respectively, by month 6 of the trial. Main cohort 1 had the concentrations of adrenaline and noradrenaline 2.1 (p < 0.05) and 1.5 (p < 0.05) times higher, respectively, vs. healthy volunteers. Main cohort 2 showed an adrenaline concentration 12.5% (p < 0.05) and noradrenaline — 2.4% higher (p = 0.15) vs. healthy volunteers.Conclusion. TES therapy affects urinary incontinence hypercatecholaminaemia, demonstrating a favourable homeostatic impact on neuroimmunoendocrine regulation.

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压力性尿失禁的高儿茶酚胺血症及其病因治疗前景：一项实验性非随机研究

背景尿失禁与慢性心理情绪压力有关。压力管理应该是尿失禁综合治疗的一部分。目标。TES治疗压力性尿失禁重复疗程中高儿茶酚胺血症严重程度和动力学的评估。方法。共有100名压力性尿失禁患者被分为两个主要队列和一个对照组。主要队列1（n=30）接受了现代标准治疗并结合TES治疗。TES治疗分为三个疗程（每天1次，持续7天）：入院时的第1疗程，第1疗程后3个月的第2疗程，第3疗程后6个月的疗程。主要队列2（n=40）接受了现代标准治疗，并结合两个短期TES治疗疗程（每天2次，持续7天）：入院时的第1疗程，第1疗程后6个月的第2疗程。对照组（n=30）仅接受标准治疗。在每个队列中评估儿茶酚胺浓度随时间的变化。后果与健康志愿者相比，所有队列中的儿茶酚胺浓度在治疗前都高出2倍以上。对比队列显示，到试验第6个月，肾上腺素和去甲肾上腺素的浓度分别比健康志愿者高71.2%（p<0.05）和84.0%（p<0.05）。与健康志愿者相比，主要队列1的肾上腺素和去甲肾上腺素浓度分别高2.1倍（p<0.05）和1.5倍（p>0.05）。主要队列2显示，与健康志愿者相比，肾上腺素浓度高12.5%（p<0.05），去甲肾上腺素高2.4%（p=0.15）。结论TES治疗可影响尿失禁高儿茶酚胺血症，对神经免疫内分泌调节具有良好的稳态影响。

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