Analysis of prognostic factors on ultrasound guided radiofrequency ablation in the treatment of primary hepatic carcinoma

Chong Zhao, T. Han, Siqi Ji, Youfa Fang, Peng Liu, Chuan Deng, Junqiang Guo
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Abstract

Objective To explore the clinical efficacy and related factors on ultrasound guided radiofrequency ablation in the treatment of primary liver cancer. Methods This retrospective study involed the patients admitted between December 2012 and July 2015.A total of 130 patients who underwent radiofrequency ablation.111 of 130 patients were followed up.The clinical efficacy was summarized and the prognostic factors was analyzed. Results The survival rate of less than 2 years was 35.1%,the survival rate of more than 2 years was 64.9%.By the single factor analysis,gender,age,hepatitis history,splenomegaly or hypersplenism,preoperative aspertate aminotransferase,preoperative alanine aminotransferase,preoperative total bilirubin and preoperative prothrombin time were not obvious influence on survival,there was no statistically significant difference(P>0.05). Child grading,lcirrhosis of liver,liver function,serum albumin,alphafetoprotein,tumor number,a single tumor diameter and the total diameter of the largest influence on patient survival was statistically significant(P<0.05). By the multifactor analysis,the maximum diameter of single tumor and serum albumin were independent prognostic factors of radiofrequency ablation. Conclusion Radiofrequency ablation is an effective treatment for liver cancer,the treatment effect is influenced by many factors.Through the analysis of related factors,it is helpful to select a better indications for clinical treatment and improve the prognosis of hepatic carcinoma. Key words: Radiofrequency ablation; Primary hepatic carcinoma; Prognosis; Related factors
超声引导下射频消融治疗原发性肝癌的预后因素分析
目的探讨超声引导下射频消融治疗原发性肝癌癌症的临床疗效及相关因素。方法本回顾性研究涉及2012年12月至2015年7月期间入院的患者。共有130名患者接受了射频消融治疗。对130名患者中的111名进行了随访。总结临床疗效,分析影响预后的因素。结果2年以下生存率为35.1%,2年以上生存率为64.9%。单因素分析,性别、年龄、肝炎史、脾肿大或脾功能亢进、术前天冬氨酸转氨酶、术前丙氨酸转氨酶、术后总胆红素和术前凝血酶原时间对生存无明显影响,差异无统计学意义(P>0.05)。患儿分级、肝功能、血清白蛋白、甲胎蛋白、肿瘤数目、单个肿瘤直径和总直径对患者生存影响最大,具有统计学意义(P<0.05),单个肿瘤的最大直径和血清白蛋白是射频消融的独立预后因素。结论射频消融是治疗癌症的有效方法,其疗效受多种因素影响。通过对相关因素的分析,有助于选择更好的临床治疗指征,改善肝癌的预后。关键词:射频消融;原发性肝癌;预后;相关因素
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