Prognostic significance of tumor deposits in patients with locally advanced gastric cancer

中华普通外科杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.1007-631X.2019.10.005

Xiaodong Huang, Yongbin Zheng, Yujie Yang, HuaLi Li, Huangrong Cheng

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Abstract

Objective To analyze the relationship between tumor deposits(TD) and clinicopathological features of locally advanced gastric cancer(LAGC) patients. Methods The clinicopathological characteristics of 300 LAGC patients undergoing radical gastrectomy in Renmin Hospital of Wuhan University from Jan 2014 to Jul 2017 were collected. The relationship between clinicopathological features and prognosis of LAGC patients and TD status in LAGC patients were analyzed retrospectively. Results TD were positive in 65(21.7%) patients. Univariate analysis showed that the depth of invasion, lymph node metastasis, pTNM stage, tumor size, vascular invasion, preoperative tumor markers were correlated with the status of TD(all P 3 was an independent risk factor for the prognosis of LAGC patients(HR=2.242, 95% CI: 1.484-3.386, P=0.000). The median survival time of TD-positive LAGC was less than TD-negative group(χ2=91.077, P 3 group was significantly shorter than that in TD number<3 group and TD-negative group(χ2=192.969, P<0.001). Conclusions TD are closely related to tumor stage in LAGC patients. The status of TD is an independent risk factor for the prognosis of LAGC. Multiple TDs indicate poor prognosis of LAGC patients. Key words: Stomach neoplasms; Prognosis; Risk factors; Tumor deposits

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局部晚期癌症患者肿瘤沉积的预后意义

目的分析局部晚期癌症（LAGC）患者肿瘤沉积（TD）与临床病理特征的关系。方法收集2014年1月至2017年7月在武汉大学人民医院接受根治性胃切除术的300例LAGC患者的临床病理特征。回顾性分析LAGC患者的临床病理特征和预后与LAGC患者TD状态的关系。结果TD阳性65例（21.7%）。单因素分析显示侵袭深度、淋巴结转移、pTNM分期、肿瘤大小、血管侵袭、，术前肿瘤标志物与TD状态相关（所有P3均为LAGC患者预后的独立危险因素（HR=2.242，95%CI:1.484-3.386，P=0.000）。TD阳性LAGC的中位生存时间小于TD阴性组（χ2=91.077，P3组明显短于TD数<3组和TD阴性组，χ2=192.969，P<0.001）与LAGC患者的肿瘤分期密切相关。TD的状况是LAGC预后的一个独立危险因素。多个TD表明LAGC患者预后不良。关键词：胃肿瘤；预后；风险因素；肿瘤沉积物

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中华普通外科杂志

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