Research progress on PET-CT in radiotherapy planning for non-small cell lung cancer

中华放射肿瘤学杂志 Pub Date : 2019-11-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2019.11.017

Ying-jie Zhang, Jianbin Li

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Abstract

18F-FDG PET-CT is recommended for the diagnosis and treatment of non-small cell lung cancer (NSCLC), and guiding the optimization of radiotherapy planning. The target area determined by biological information carried by functional images is defined as biological target volume (BTV). However, BTV significantly differs from the gross tumor volume (GTV) and internal target volume (ITV) defined by the International Commission on Radiation Units and Measurements (ICRU) report. It is still a challenging task to directly apply BTV to radiotherapy planning. The limitation of PET image, the accuracy of fusion with auxiliary anatomic images and the influence of respiratory movement cause the uncertainty of BTV definition in NSCLC patients. Referring to different anatomical images, multiple approaches can be employed to achieve BTV motion information compensation. Application of PET-CT in predicting the prognosis of NSCLC patients after radiotherapy and distinguishing the recurrence risk of biological sub-target contribute to achieving the dose planning for radiotherapy planning. Key words: Non-small cell lung cancer; Radiotherapy planning; Positron emission tomography-computed tomography

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PET-CT在非小细胞肺癌放疗计划中的研究进展

推荐18F-FDG PET-CT用于癌症（NSCLC）的诊断和治疗，并指导放疗计划的优化。由功能图像携带的生物信息确定的目标区域被定义为生物目标体积（BTV）。然而，BTV与国际辐射单位和测量委员会（ICRU）报告定义的总肿瘤体积（GTV）和内靶体积（ITV）有显著差异。将BTV直接应用于放射治疗规划仍然是一项具有挑战性的任务。PET图像的局限性、与辅助解剖图像融合的准确性以及呼吸运动的影响导致了非小细胞肺癌患者BTV定义的不确定性。参考不同的解剖图像，可以采用多种方法来实现BTV运动信息补偿。PET-CT在预测NSCLC患者放疗后预后和区分生物亚靶点复发风险方面的应用有助于实现放疗计划的剂量规划。关键词：非小细胞肺癌；放射治疗计划；正电子发射断层扫描计算机断层扫描

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华放射肿瘤学杂志

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6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.