Correlation between serum uric acid and coronary collateral circulation in patients with coronary chronic total occlusion

Q4 Medicine

Cardiology Plus Pub Date : 2022-10-01 DOI:10.1097/CP9.0000000000000033

Jing Li, H. Pei, Xianglin Ye, Jing Tian, Haixiang Yang, Qing Liu, Xiong Wang, Peng Wang

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引用次数: 1

Abstract

Background and purpose: Previous studies showed urate crystals in atherosclerotic plaques, suggesting that uric acid is involved in plaque formation, but whether it affects the formation of coronary collateral circulation (CCC) is unknown. This single-center retrospective study was conducted to investigate whether serum uric acid (SUA) level has an association with the CCC in patients with coronary chronic total occlusion (CTO). Methods: The final analysis included a total of 94 patients with CTO (defined as 100% stenosis in at least one of the left anterior descending artery, circumflex artery and right coronary artery with thrombolysis in myocardial infarction [TIMI] grade 0 of forward flow) for more than 3 months (66.03 ± 10.10 years of age; 54 men and 40 women). In the analysis, patients were divided into four groups of equal size based on the SUA level on admission (n = 32, 31, 31 for low, mid, and high SUA groups). Multivariate logistic regression was conducted to identify risk factors that were associated with poor CCC (as defined by Rentrop level ≤ 1). Results: The rate of poor CCC was 44.5% in the low SUA group, 54.8% in the mid-SUA group, and 77.4% in the high SUA group, respectively (P < 0.05 for all three pairwise comparisons). In multivariate regression analysis that treated SUA as a continuous variable, poorer CCC was associated with higher SUA (adjusted odds ratio [OR] = 1.011, 95% confidence interval [CI]: 1.005–1.017, P < 0.05). In comparison to the patients with lowest SUA in the regression analysis that treated SUA as a categorical variable, there was a statistically non-significant trend for increased risk of poor CCC (OR 2.277, 95% CI: 0.753–6.884) in the patient with mid-level SUA. The risk of poor CCC was significantly elevated in the patients with high SUA (OR 6.243, 95% CI: 1.872–20.828). Conclusions: Elevated SUA level was associated with poor CCC in patients with CTO.

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冠状动脉慢性完全闭塞患者血清尿酸与冠状动脉侧支循环的相关性

背景和目的：先前的研究表明，尿酸盐晶体存在于动脉粥样硬化斑块中，这表明尿酸参与了斑块的形成，但它是否影响冠状动脉侧支循环（CCC）的形成尚不清楚。这项单中心回顾性研究旨在调查血清尿酸（SUA）水平是否与冠状动脉慢性完全闭塞（CTO）患者的CCC相关。方法：最终分析包括94例CTO（定义为左前降支、回旋支和右冠状动脉中至少一条100%狭窄，并在心肌梗死[TIMI]0级正向流中溶栓）超过3个月（66.03 ± 10.10岁；54名男性和40名女性）。在分析中，根据入院时的SUA水平，将患者分为四组，每组人数相等（n = 低、中、高SUA组为32、31、31）。进行多变量逻辑回归，以确定与CCC不良相关的风险因素（由Rentrop水平定义 ≤ 1）。结果：低SUA组CCC不良率为44.5%，中SUA组为54.8%，高SUA组则为77.4%（P < 对于所有三个成对比较为0.05）。在将SUA视为连续变量的多元回归分析中，CCC越差，SUA越高（调整比值比[OR] = 1.011，95%置信区间[CI]：1.005–1.017，P < 0.05）。在将SUA视为分类变量的回归分析中，与SUA最低的患者相比，中度SUA患者CCC不良风险增加的趋势在统计学上不显著（OR 2.277，95%CI:0.753-6.884）。SUA高的患者CCC不良的风险显著升高（OR 6.243，95%CI:1.872–20.828）。结论：CTO患者SUA水平升高与CCC不良有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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