Epigenetic mechanisms of bronchopulmonary dysplasia: a review

Q4 Medicine

中华围产医学杂志 Pub Date : 2020-01-16 DOI:10.3760/CMA.J.ISSN.1007-9408.2020.01.011

Peijuan Chen, Zhiting Wan, Bao-huan Cai, Wenbin Li

引用次数: 0

Abstract

Bronchopulmonary dysplasia (BPD) is a common chronic respiratory complication in preterm infants without fully understand the mechanism or effective treatment, which could significantly affect the survival rate and prognosis of these infants. Studies have confirmed that epigenetic mechanisms, including histone modification, non-coding RNA and DNA methylation may play an essential role in the onset and development of BPD. And most related epigenetic changes are reversible, which might serve as a potential target for BPD treatment. Therefore, further studies on epigenetics will shed light on a better understanding of the pathogenesis, prevention, and treatment of BPD. Key words: Bronchopulmonary dysplasia; Epigenomics; Histone code; RNA, untranslated; DNA methylation

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支气管肺发育不良的表观遗传机制综述

支气管肺发育不良（BPD）是早产儿常见的慢性呼吸道并发症，在不完全了解其发病机制或有效治疗的情况下，可能会严重影响这些婴儿的生存率和预后。研究证实，表观遗传学机制，包括组蛋白修饰、非编码RNA和DNA甲基化，可能在BPD的发病和发展中发挥重要作用。大多数相关的表观遗传学变化是可逆的，这可能是BPD治疗的潜在靶点。因此，对表观遗传学的进一步研究将有助于更好地了解BPD的发病机制、预防和治疗。关键词：支气管肺发育不良；表观基因组学；直方图编码；RNA，未翻译；DNA甲基化

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华围产医学杂志 Medicine-Obstetrics and Gynecology

CiteScore

0.70

自引率

0.00%

发文量

4446

期刊介绍： Chinese Journal of Perinatal Medicine was founded in May 1998. It is one of the journals of the Chinese Medical Association, which is supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by Peking University First Hospital. Perinatal medicine is a new discipline jointly studied by obstetrics and neonatology. The purpose of this journal is to "prenatal and postnatal care, improve the quality of the newborn population, and ensure the safety and health of mothers and infants". It reflects the new theories, new technologies, and new progress in perinatal medicine in related disciplines such as basic, clinical and preventive medicine, genetics, and sociology. It aims to provide a window and platform for academic exchanges, information transmission, and understanding of the development trends of domestic and foreign perinatal medicine for the majority of perinatal medicine workers in my country.