Serum interleukin-6 and high sensitivity C-reactive protein levels and their correlation with the vitiligo disease activity and extent: A cross-sectional study of 58 patients.

Q3 Medicine
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-07-01 Epub Date: 2023-08-04 DOI:10.4103/JCAS.JCAS_12_23
Bhargavi M Uttmani, Keshavmurthy A Adya, Arun C Inamadar
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引用次数: 0

Abstract

Vitiligo is an acquired depigmenting disorder due to the destructive loss of melanocytes, clinically presenting as hypopigmented or depigmented macules and/or patches. Many theories have been proposed to explain its etiopathogenesis among which cell-mediated immunity is one of the crucial links. Estimation of vitiligo activity and extent in a patient is important in tailoring an optimal treatment regimen. Interleukin-6 (IL-6) and high-sensitivity C-reactive protein (HsCRP) are sensitive indicators for systemic inflammation and are found to be relevant in determining vitiligo disease activity. This study was conducted to estimate serum levels of IL-6 and HsCRP in vitiligo patients and to correlate them with the disease activity and extent in order to assess if these serum markers serve as objective indicators of vitiligo disease activity. This was a hospital-based cross-sectional study of 58 vitiligo patients diagnosed clinically irrespective of age, gender, and any ongoing or past treatment. Disease activity and extent were calculated using the vitiligo disease activity (VIDA) score and vitiligo area severity index (VASI), respectively. Serum levels of IL-6 and HsCRP were obtained and their correlation with VIDA and VASI values were statistically analyzed. A weak negative statistically insignificant correlation was found between IL-6 and VIDA (P = 0.092). No correlation was found between VIDA and HsCRP (P = 0.998). A weak positive, statistically insignificant correlation was found between VASI and IL-6 as well as between VASI and HsCRP (P = 0.175 and P = 0.238, respectively). Although statistically insignificant, the patients who were not on immunosuppressive therapy showed higher mean values of IL-6 and HsCRP compared to those who were on immunosuppressive therapy. In contrast to the findings of previous studies, our study found a weak negative correlation between VIDA and IL-6 levels possibly attributable to the difference between the mean levels of IL-6 among the subgroups of patients who were, and were not on immunosuppressive therapy. The VIDA score and HsCRP levels did not show any statistical correlation. However, patients who were not on immunosuppressive therapy showed a higher albeit statistically insignificant mean value of HsCRP. Our observations suggest that any ongoing and/or treatment in the recent past, especially immunosuppressive therapy, and any co-morbidities should be essentially considered while investigating for sensitive serum markers of inflammation as determinants of vitiligo disease activity.

58例白癜风患者血清白介素-6和高敏c反应蛋白水平及其与疾病活动性和程度的相关性研究
白癜风是一种由于黑色素细胞破坏性缺失而引起的后天性色素脱失性疾病,临床表现为色素减退或色素脱失的黄斑和/或斑块。人们提出了许多理论来解释其发病机制,其中细胞介导的免疫是关键环节之一。评估患者的白癜风活动和程度对于制定最佳治疗方案很重要。白细胞介素-6(IL-6)和高敏C反应蛋白(HsCRP)是全身炎症的敏感指标,并被发现与确定白癜风疾病活动性有关。本研究旨在评估白癜风患者的血清IL-6和HsCRP水平,并将其与疾病活动性和程度相关联,以评估这些血清标志物是否可以作为白癜风疾病活动性的客观指标。这是一项基于医院的横断面研究,对58名临床诊断的白癜风患者进行了研究,无论其年龄、性别以及任何正在进行或过去的治疗。分别使用白癜风疾病活动性(VIDA)评分和白癜风区域严重程度指数(VASI)计算疾病活动性和程度。获得血清IL-6和HsCRP水平,并统计分析它们与VIDA和VASI值的相关性。IL-6和VIDA之间存在微弱的负相关(P=0.092)。VIDA和HsCRP之间没有相关性(P=0.998)。VASI和IL-6之间以及VASI和HsCRP间存在微弱的正相关(分别为P=0.175和P=0.238)。尽管在统计学上不显著,但与接受免疫抑制治疗的患者相比,未接受免疫抑制疗法的患者显示出更高的IL-6和HsCRP平均值。与之前的研究结果相反,我们的研究发现,VIDA和IL-6水平之间存在微弱的负相关性,这可能是由于接受和不接受免疫抑制治疗的患者亚组的IL-6平均水平之间的差异。VIDA评分和HsCRP水平没有显示出任何统计学相关性。然而,未接受免疫抑制治疗的患者显示出较高的HsCRP平均值,尽管在统计学上不显著。我们的观察结果表明,在研究作为白癜风疾病活动决定因素的炎症敏感血清标志物时,应基本考虑最近正在进行的和/或治疗,特别是免疫抑制治疗,以及任何合并症。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
60
审稿时长
29 weeks
期刊介绍: The journal will cover aspects of Dermatosurgery and Aesthetic surgery, including cutaneous surgical procedures, lasers, light based treatments and aesthetic treatments. Authors of articles addressing topics such as skin tumours, pigmentary disorders, histopathology, diagnostic techniques, drugs, applications of cosmeceuticals surgical aspects, including pre and post procedural care are highly encouraged to submit with us. The journal also publishes articles on topics in allied specialities suh as plastic surgery, maxillofacial surgery vascular surgery, oculoplastic surgery etc. that are relevant to Dermatosurgery. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed Original Research Articles, Systematic reviews, Narrative Reviews, Case reports, Innovations and Debates. Letters to the editor, practice points, pearls in cutaneous and aesthetic surgery, quiz page, images, novel techniques, newer uses of instruments and video presentations and ethical aspects of cutaneous and aesthetic surgery are also invited.
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