Association between periodontitis and metabolic syndrome: A review

Abstract

Periodontitis and metabolic syndrome (MetS) are concerning issues affecting well-being and are prevalent. The MetS comprises a conglomerate of numerous physical conditions that occur concurrently, as well as intensifying the likelihood of heart disease and type 2 diabetes mellitus (T2DM). Periodontitis is a microbial oral condition that causes the loss of tooth attachment and can proceed to edentulism if left untreated. Epidemiologic, experimental, and interventional studies have documented that periodontitis could have a consequence on systemic health and share a common pathway with several chronic noncommunicable diseases, namely DM, cardiovascular disease, and MetS. Current data suggest that periodontitis may promote the onset or acceleration of MetS. The overall oxidative load and overactive inflammatory repercussions could be responsible for this interaction. As a result, it is crucial to comprehend the current condition of the association as well as the prospective contribution of periodontitis to MetS. The findings of published studies that provide consistent data on the varied outcomes of periodontitis on MetS are encapsulated in this review. Systematic reviews, meta-analyses, original studies, and review articles were appraised in synthesizing this review, using PubMed and Google Scholar search engines.