DISTRIBUTION OF NON-MALIGNANT HEMATOLOGICAL DISORDERS BY SEX, AGE GROUPS AND TYPE OF DISEASE BASED ON BONE MARROW ASPIRATION IN POPULATION OF KHYBER PAKHTUNKHWA, PAKISTAN

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL

Gomal Journal of Medical Sciences Pub Date : 2019-06-30 DOI:10.46903/17.02.1926

Mohammad Riazuddin Ghori, Hamzullah Khan, M. Marwat

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引用次数: 9

Abstract

Background: The distribution of non-malignant hematological disorder varies across globe by sex, age groups and type of disease. The objectives of this study were to determine distribution of non-malignant hematological disorders by sex, age groups and type of disease based on bone marrow aspiration in population of Khyber Pakhtunkhwa, Pakistan. Materials and Methods: This cross-sectional study was conducted in Department of Pathology, Khyber Teaching Hospital, Peshawar, Pakistan from Jan.-Dec. 2014. 116 cases with non-malignant hematogical disorders were selected. Sex, age groups and type of disease were analyzed by count and percentage with confidence intervals for proportions. Chi-square goodness-of-fit test was used to testify two hypotheses. Results: Out of 116 cases, 63(54.31%, 80%CI 48.38-60.24) were men and 53(45.69%, 80% CI 39.76-51.62) women. Age groups wise; 31(26.72%, 80%CI 21.46-31.99) were child (≤17 years), 57(49.14%, 80%CI 43.19-55.09) young adult (18-35 years), 19(16.38%, 80%CI 11.98-20.78) middle-aged adults (36-55 years) and nine (7.76%, 80%CI 4.57-10.94) older adults (≥56 years). Frequency of type of disease was; hemolytic anemia 17(14.66%, 80%CI 10.45-18.86), megaloblastic anemia 16(13.79%, 80%CI 9.69-17.9), bone marrow hypoplasia 14(12.07%, 80%CI 8.19-15.95), iron deficiency anemia 13(11.21%, 80%CI 7.45-14.96), mixed deficiency anemia 9(7.76%, 80%CI 4.57-10.94), ITP 9(7.76%, 80%CI 4.57-10.94), aplastic anemia 8(6.89%, 80%CI 3.88-9.91), bi-liniage cytopenia 7(6.03%, 80%CI 3.2-8.87), erythroid hyperplasia 3(2.59%, 80%CI .7-4.47) and malaria 2(1.72%, 80%CI 0.18-3.27). In 18(15.52%, 80%CI 11.21-19.83) cases the bone marrow was diluted. Null hypothesis for distribution of sex (p=.3532) was accepted while that for age groups was rejected (p=

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基于骨髓抽吸的巴基斯坦开伯尔-普赫图赫瓦地区人群中非恶性血液病的性别、年龄组和疾病类型分布

背景：非恶性血液病在全球的分布因性别、年龄组和疾病类型而异。本研究的目的是根据骨髓抽吸，确定巴基斯坦开伯尔-普赫图赫瓦地区人群中非恶性血液病的性别、年龄组和疾病类型分布。材料和方法：这项横断面研究于2014年1月至12月在巴基斯坦白沙瓦开伯尔教学医院病理科进行。选择116例非恶性血液病患者。通过计数和百分比对性别、年龄组和疾病类型进行分析，并对比例进行置信区间。卡方拟合优度检验用于验证两个假设。结果：116例中，男性63例（54.31%，80%CI48.38-60.24），女性53例（45.69%，80%CI 39.76-51.62）。按年龄组划分；儿童（≤17岁）31例（26.72%，80%CI 21.46-31.99），青年（18-35岁）57例（49.14%，80%CI43.19-55.09），中年（36-55岁）19例（16.38%，80%CI11.98-20.78），老年（≥56岁）9例（7.76%，80%Ci4.57-10.94）。疾病类型的频率为；溶血性贫血17（14.66%，80%CI 10.45-18.86），巨幼细胞性贫血16（13.79%，80%CI 9.69-17.9），骨髓发育不全14（12.07%，80%CI 8.19-15.95，红细胞增生3例（2.59%，80%CI.7-4.47）和疟疾2例（1.72%，80%CI.18~3.27）。性别分布的零假设（p=.3532）被接受，而年龄组的零假设被拒绝（p=

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