PLACENTAL ALPHA-MICROGLOBULIN 1 AS A MARKER OF PRETERM PRELABOUR RUPTURE OF MEMBRANE

Abstract

Background:Normal pregnancy requires that the physical integrity of the fetal membranes be maintained until term delivery. Objective:To detect preterm prelabour rupture of membrane in pregnant women with history of watery vaginal discharge by measurement of placental alpha microglobulin 1 in cervicovaginal fluid. Methods:A case-control study done at the department of Obstetrics and Gynecology of Al-Imamein Al-Kadhimein Medical City, included 100 pregnant women attending the Outpatient Clinic with a gestational age ranging between 28-36 weeks +6 days, 50 cases with rupture of membrane (study group) and 50 cases without any complaint (control group). All women underwent sterile speculum vaginal examination then nitrazine paper used, finally placental alpha microglobulin1 level was measured by using enzyme linked immunosorbent assay kit in vaginal washing fluid. Results:A highly significant association was found between mean of placental alpha microglobulin 1 in vaginal fluid of women with premature rupture of membrane compared to the control. The validity results of placental alpha microglobulin 1 findings regarding premature rupture of membrane include: sensitivity (100%), specificity (98.0%), +ve predictive value (98.1%), -ve predictive value (100%) and accuracy (99.0%), while for nitrazine; the sensitivity (94.0%), specificity (90.0%), +ve predictive value (90.4%), -ve predictive value (93.7%) and accuracy (92%) and for vaginal fluid sensitivity (80.0%), specificity (72.0%), +ve predictive value (74.1%), -ve predictive value (78.3%) and accuracy (76.0%). Conclusion:The placental alpha microglobulin-1 immunoassay in vaginal fluid wash found to be accurate and noninvasive test, in identifying preterm prelabour rupture of the membrane. Keywords:Placental alpha-microglobulin1, preterm prelabour rupture of membrane, prelabour rupture of membrane Citation:Seger SH, Al-Moayed HA, Abdulrasul EA, Mushatat SH. Placental alpha-microglobulin 1 as a marker of preterm prelabour rupture of membrane. Iraqi JMS. 2019; 17(3&4): 183-190. doi: 10.22578/IJMS.17.3&4.4