Anti-coronavirus properties of brassinosteroids

IF 0.1 Q4 MULTIDISCIPLINARY SCIENCES

DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI Pub Date : 2023-09-01 DOI:10.29235/1561-8323-2023-67-4-295-299

V. Zhabinskii, Alexey M. Matorin, O. Savinova, E. Boreko, Academician Vladimir A. Khripach, Член-корреспондент В. Н. Жабинский, А. М. Маторин, О.В. Савинова, Е.И. Бореко, В. А. Хрипач

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Abstract

Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.

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油菜素甾体的抗冠状病毒特性

以季节性人类呼吸系统α冠状病毒229E（HCoV-229E）为例，研究了campestane、麦角甾烷和豆甾烷系列的天然油菜素甾体（6-酮和B-内酯）及其（22S，23S）-类似物的抗病毒特性。许多研究的化合物显示出抗冠状病毒的特性。一般来说，6-酮比B-内酯更具活性。（22S，23S）-表雄酮对HCoV-229E繁殖的抑制作用最大（EC50 21.1µM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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