Study of Plasma Anti-CD26 Autoantibody Levels in a Cohort of Treatment-Naïve Early Arthritis Patients

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Oscar J. Cordero, Irene Viéitez, Irene Altabás, Laura Nuño-Nuño, Alejandro Villalba, Marta Novella-Navarro, Diana Peiteado, María-Eugenia Miranda-Carús, Alejandro Balsa, Rubén Varela-Calviño, Iria Gomez-Tourino, José M. Pego-Reigosa
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引用次数: 2

Abstract

In rheumatoid arthritis (RA), the identification of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We proposed that autoantibodies (aAbs) against CD26 (DPP4) might have both etiological importance and clinical value. Here, we perform a prospective study of the potential diagnostic power of Anti-CD26 aAbs through their quantification in plasmas from 106 treatment-naïve early and undifferentiated AR. Clinical antibodies, Anti-CD26 aAbs, and other disease-related biomarkers were measured in plasmas obtained in the first visit from patients, which were later classified as RA and non-RA according to the American College of Rheumatology criteria. Two different isotype signatures were found among ten groups of patients, one for Anti-CD26 IgA and other for Anti-CD26 IgG and IgM isotypes, both converging in patients with arthritis (RA and Unresolved Undifferentiated Arthritis: UUA), who present elevated levels of all three isotypes. The four UUA patients, unresolved after two years, were ACPA and rheumatic factor (RF) negatives. In the whole cohort, 51.3% of ACPA/RF seronegatives were Anti-CD26 positives, and a similar frequency was observed in the seropositive RA patients. Only weak associations of the three isotypes with ESR, CRP and disease activity parameters were observed. Anti-CD26 aAbs are present in treatment-naïve early arthritis patients, including ACPA and RF seronegative individuals, suggestive of a potential pathogenic and/or biomarker role of Anti-CD26 aAbs in the development of rheumatic diseases.

早期关节炎患者血浆抗CD26自身抗体水平的研究
在类风湿性关节炎(RA)中,确定生物标志物以调整治疗强度并在早期阶段正确诊断疾病仍然是一个挑战,因此需要新的生物标志物。我们认为抗CD26 (DPP4)的自身抗体(aAbs)可能具有病原学意义和临床价值。在这里,我们通过对106例treatment-naïve早期和未分化AR患者血浆中抗cd26单克隆抗体的定量研究,对其潜在的诊断能力进行了前瞻性研究。临床抗体、抗cd26单克隆抗体和其他疾病相关的生物标志物在患者首次就诊时获得的血浆中进行了测量,随后根据美国风湿病学会的标准将这些患者分为RA和非RA。在10组患者中发现了两种不同的同型特征,一种是抗cd26 IgA,另一种是抗cd26 IgG和IgM同型,这两种特征在关节炎(RA和未解决的未分化关节炎:UUA)患者中汇合,这些患者的三种同型水平均升高。4例UUA患者,两年后未确诊,ACPA和风湿因子(RF)阴性。在整个队列中,51.3%的ACPA/RF血清阴性患者为Anti-CD26阳性,在血清阳性RA患者中观察到相似的频率。三种亚型仅与ESR、CRP和疾病活动性参数存在弱相关性。抗cd26单克隆抗体存在于treatment-naïve早期关节炎患者中,包括ACPA和RF血清阴性个体,提示抗cd26单克隆抗体在风湿性疾病的发展中具有潜在的致病性和/或生物标志物作用。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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