Tocotrienol-rich vitamin E from palm oil (Tocovid) and its effects in diabetes and diabetic retinopathy: a pilot phase II clinical trial

Q4 Medicine

Asian Journal of Ophthalmology Pub Date : 2021-04-16 DOI:10.35119/ASJOO.V17I4.698

Yilynn Chiew, Suzanne May Quinn Tan, B. Ahmad, Sim Ee Khor, K. A. Kadir

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引用次数: 2

Abstract

Aim: To identify the effects of tocotrienol-rich vitamin E from palm oil (Tocovid) on diabetic retinopathy (DR) in patients with type 2 diabetes. Materials and methods: The intervention group (n = 21) received 200 mg Tocovid twice daily while the control group (n = 22) received placebo twice daily for 8 weeks. Changes in retinal photography by conventional grading and novel quantification of retinal hemorrhage were assessed. Changes in serum biomarkers advanced glycation end products (AGE) general, sRAGE (soluble receptor of AGE), Ne-CML (specific type of AGE), and cystatin C were evaluated. Results: A novel technique to quantify retinal hemorrhage had a strong positive correlation with conventional grading of DR in both eyes at baseline and at the end of the study. Eight-week supplementation of Tocovid resulted in significant reduction in retinal hemorrhage in the right eye. Liver enzymes and ALT significantly reduced. No significant changes in grade of DR, serum biomarkers, HbA1c, blood pressure, renal profile, and lipid profile were observed. Conclusions: Tocovid is a potential adjunct to current treatment of DR and fatty liver disease. A novel method of quantifying retinal hemorrhage is a potential technique for assessing disease severity of DR, particularly the early changes.

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棕榈油中富含生育三烯醇的维生素E (Tocovid)及其对糖尿病和糖尿病视网膜病变的影响:一项II期临床试验

目的:探讨棕榈油中富含生育三烯醇的维生素E (Tocovid)对2型糖尿病患者糖尿病视网膜病变(DR)的影响。材料与方法:干预组(n = 21)给予Tocovid 200 mg，每日2次;对照组(n = 22)给予安慰剂，每日2次，连续8周。通过传统的分级和新的定量视网膜出血评估视网膜摄影的变化。评估血清生物标志物晚期糖基化终产物(AGE)、AGE可溶性受体(sRAGE)、Ne-CML(特异性AGE)和胱抑素C的变化。结果:一种量化视网膜出血的新技术与基线和研究结束时双眼DR的常规分级有很强的正相关。补充Tocovid 8周后，右眼视网膜出血显著减少。肝酶和ALT显著降低。DR的等级、血清生物标志物、HbA1c、血压、肾脏特征和血脂特征均无显著变化。结论:Tocovid是当前DR和脂肪肝治疗的潜在辅助手段。一种量化视网膜出血的新方法是评估DR疾病严重程度的潜在技术，特别是早期的变化。

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来源期刊

Asian Journal of Ophthalmology Medicine-Ophthalmology

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期刊介绍： Asian Journal of OPHTHALMOLOGY is the official peer-reviewed journal of the South East Asia Glaucoma Interest Group (SEAGIG) and is indexed in EMBASE/Excerpta Medica. Asian Journal of OPHTHALMOLOGY is published quarterly (four [4] issues per year) by Scientific Communications International Limited. The journal is published on-line only and is distributed free of cost via the SEAGIG website.