Prognostic value of D-dimer to fibrinogen ratio for patients with acute myocardial infarction

IF 0.6 4区医学 Q4 IMMUNOLOGY

European Journal of Inflammation Pub Date : 2022-01-01 DOI:10.1177/1721727X221132381

Litao Zhang, Jia-Suo Jiang, Jie Li, Min Wang, Jun Zhou

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引用次数: 1

Abstract

Objective Myocardial infarction is a severe disease with high in-hospital mortality without aggressive clinical treatment. The study aims to evaluate prognostic worth of D-dimer-to-fibrinogen (FIB) ratio (DFR) for patients with acute myocardial infarction (AMI). Methods 133 patients (65 (37, 93) years old) from our hospital (China) with AMI were enlisted from January 2017 to December 2019. Patients were assigned into the survivor and nonsurvivor group based on in-hospital outcomes. Receiver operating characteristics (ROC) and multivariate analysis were fulfilled to analyze the prognostic value of DFR. Results The degree of DFR in the nonsurvivor group was significantly higher than that in the survivor group (p < 0.05). Logistic regression analysis presented that DFR (hazard ratio (HR), 2.207; 95% confidence interval (CI), 1.050–4.640; p = 0.037) was independently related with in-hospital death. ROC demonstrated that the area under the curve (AUC) of DFR was = 0.808 (0.725–0.892) (sensitivity, 85.3%; specificity, 69.7%). Conclusion DFR might be a new independent predictor of in-hospital death for AMI patients. Further studies are needed to validate this preliminary finding.

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D-二聚体与纤维蛋白原比值对急性心肌梗死患者的预后价值

目的心肌梗死是一种未经积极临床治疗，住院死亡率高的严重疾病。本研究旨在评估D-二聚体与纤维蛋白原（FIB）比值（DFR）对急性心肌梗死（AMI）患者的预后价值。方法收集我院2017年1月至2019年12月收治的133例AMI患者（65（37，93）岁）。根据住院结果将患者分为幸存者组和非幸存者组。采用受试者操作特征（ROC）和多变量分析来分析DFR的预后价值。结果非幸存者组DFR程度明显高于幸存者组（p＜0.05），Logistic回归分析显示：DFR（HR）为2.207；95%置信区间（CI），1.050~4.640；p=0.037）与住院死亡独立相关。ROC显示DFR的曲线下面积（AUC）=0.808（0.725–0.892）（敏感性，85.3%；特异性，69.7%）。结论DFR可能是AMI患者住院死亡的一个新的独立预测指标。需要进一步的研究来验证这一初步发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Inflammation 医学-免疫学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.