Recent advance in functionalized mesoporous silica nanoparticles with stimuli-responsive polymer brush for controlled drug delivery

IF 1.6 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Soft Materials Pub Date : 2022-01-15 DOI:10.1080/1539445X.2022.2028831

L. Alfhaid

引用次数: 6

Abstract

ABSTRACT Mesoporous silica nanoparticles (MSNs) are considered a highly promising candidate for novel the drug delivery systems (DDSs) due to the possibility of controlling their functionalizable pores, their large pore volume, high loading cavities and biocompatibility. MSNs functionalized with stimuli-responsive polymers have been demonstrated to represent a controllable and smart drug delivery application able to release drugs in response to certain stimuli, including pH, temperature, light, enzyme or redox. The surface of the MSNs is coated with stimuli-responsive polymer brushes so as to increase the stability and extend the release period of the loaded drug. This minireview highlights the latest research developments of polymer-brush-grafted MSNs and their potential biomedical applications in this area.

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具有刺激响应聚合物刷的功能化介孔二氧化硅纳米颗粒用于控制药物递送的最新进展

摘要：中孔二氧化硅纳米颗粒（MSNs）由于其可控制的功能孔、大孔体积、高负载空腔和生物相容性，被认为是新型药物递送系统（DDS）的一种非常有前途的候选者。用刺激响应性聚合物功能化的MSNs已被证明是一种可控和智能的药物递送应用，能够响应某些刺激释放药物，包括pH、温度、光、酶或氧化还原。MSNs的表面涂覆有刺激响应性聚合物刷，以增加负载药物的稳定性并延长其释放期。这篇小型综述重点介绍了聚合物刷接枝MSNs的最新研究进展及其在该领域的潜在生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Soft Materials 工程技术-材料科学：综合

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Providing a common forum for all soft matter scientists, Soft Materials covers theory, simulation, and experimental research in this rapidly expanding and interdisciplinary field. As soft materials are often at the heart of modern technologies, soft matter science has implications and applications in many areas ranging from biology to engineering. Unlike many journals which focus primarily on individual classes of materials or particular applications, Soft Materials draw on all physical, chemical, materials science, and biological aspects of soft matter. Featured topics include polymers, biomacromolecules, colloids, membranes, Langmuir-Blodgett films, liquid crystals, granular matter, soft interfaces, complex fluids, surfactants, gels, nanomaterials, self-organization, supramolecular science, molecular recognition, soft glasses, amphiphiles, foams, and active matter. Truly international in scope, Soft Materials contains original research, invited reviews, in-depth technical tutorials, and book reviews.