Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal

M. Das, Rashmita Bhandari
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Abstract

Background: Cervical cancer is a leading health problem among women all over the world with significant mortality and morbidity in developing countries like Nepal. Pap smear is an effective and cost efficient diagnostic technique for cervical lesions. This study aims at histopathological correlation of cervical Pap smears. Materials and Methods: A cross sectional study was conducted from January 2020 to January 2022 in Pathology department of Nobel Medical College Teaching Hospital (NMCTH). 119 cases of cervical Pap smear were reported using the Bethesda system and correlated with histopathological examination findings for various epithelial cell abnormalities. Analysis was done using SPSS software version 20. Results: Out of 5110 smears examined, 119 were positive for epithelial cell abnormalities. Cellular abnormality was commonly seen between 31-60 years of age. Low grade Squamous Intraepithelial Lesion was the commonest lesion found. Pap smear findings had good concordance rates with histopathological findings for individual lesions. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Pap smear were 84%, 23.1%, 89.9%, 15% and 77.3% respectively. Conclusion: Pap smear has a good diagnostic accuracy, sensitivity and positive predictive value in diagnosing cervical lesions in comparison to histopathological examination
尼泊尔东部一家三级护理中心患者宫颈巴氏涂片中上皮细胞异常与组织病理学相关性
背景:癌症是世界各地妇女的主要健康问题,在尼泊尔等发展中国家死亡率和发病率很高。巴氏涂片是一种有效且经济高效的宫颈病变诊断技术。本研究旨在探讨子宫颈巴氏涂片的组织病理学相关性。材料与方法:于2020年1月至2022年1月在诺贝尔医学院教学医院病理科进行横断面研究。使用Bethesda系统报告了119例宫颈巴氏涂片,并与各种上皮细胞异常的组织病理学检查结果相关。使用SPSS软件版本20进行分析。结果:在检查的5110份涂片中,119份上皮细胞异常呈阳性。细胞异常常见于31-60岁之间。低级别鳞状上皮内病变是最常见的病变。巴氏涂片检查结果与个别病变的组织病理学检查结果具有良好的一致性。巴氏涂片的总体敏感性、特异性、阳性预测值、阴性预测值和诊断准确率分别为84%、23.1%、89.9%、15%和77.3%。结论:巴氏涂片与组织病理学检查相比,具有良好的诊断准确性、敏感性和阳性预测价值
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