Neurogenic Hyperprolactinemia

Cardiometry Pub Date : 2023-08-25 DOI:10.18137/cardiometry.2023.28.1926

K.A. Arzumanyan, S. Levchenko, A.S. Bolvakh, E.E. Dyba, M.A Mesyan, A.D. Matyushenko

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Abstract

Neurogenic hyperprolactinemia is a rather rare clinical form of hyperprolactinemia, therefore, this pathology may escape the attention of clinicians. At the same time, a high level of prolactin in blood can result in severe metabolic disorders, infertility, decreased bone tissue density, obesity, increased insulin resistance, and poor lipid metabolism. If the disease is not diagnosed in time, it will lead not only to the significantly decreased health and life quality level, but can also contribute to the increased risk of breast cancer formation. The main reason for the development of neurogenic hyperprolactinemia can be various pathological processes in chest, spinal cord and mammary glands. The neurogenic mechanism is triggered by the activation of afferent impulses going to the posterior sections of the spinal cord. The main diagnostic tactics is the exclusion of the most common causes of hyperprolactinemia, identification of the pathological process in the thoracic region, and detection of high prolactin level in the blood serum. Taking the pathogenetic mechanism into account, the treatment of neurogenic hyperprolactinemia consists in eliminating the pathological focus and prescribing dopamine agonists. The purpose of this article is to define the main clinical features associated with the diagnosis and treatment of neurogenic hyperprolactinemia.

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神经源性高泌乳素血症

神经源性高催乳素血症是一种相当罕见的临床形式的高催乳素血症，因此，这种病理可能逃避临床医生的注意。同时，血液中催乳素水平过高会导致严重的代谢紊乱、不孕症、骨组织密度下降、肥胖、胰岛素抵抗增加和脂质代谢不良。如果不及时诊断，不仅会导致健康和生活质量水平的显著下降，而且还可能导致乳腺癌形成的风险增加。胸、脊髓和乳腺的各种病理过程可能是导致神经源性高泌乳素血症发生的主要原因。神经源性机制是由进入脊髓后段的传入冲动的激活触发的。主要的诊断策略是排除高催乳素血症最常见的病因，确定胸区病理过程，检测血清中高催乳素水平。考虑到发病机制，神经源性高泌乳素血症的治疗包括消除病理病灶和处方多巴胺激动剂。本文的目的是明确与神经源性高泌乳素血症的诊断和治疗相关的主要临床特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiometry MEDICAL LABORATORY TECHNOLOGY-

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Cardiometry is an open access biannual electronic journal founded in 2012. It refers to medicine, particularly to cardiology, as well as oncocardiology and allied science of biophysics and medical equipment engineering. We publish mainly high quality original articles, reports, case reports, reviews and lectures in the field of the theory of cardiovascular system functioning, principles of cardiometry, its diagnostic methods, cardiovascular system therapy from the aspect of cardiometry, system and particular approaches to maintaining health, engineering peculiarities in cardiometry developing. The interdisciplinary areas of the journal are: hemodynamics, biophysics, biochemistry, metrology. The target audience of our Journal covers healthcare providers including cardiologists and general practitioners, bioengineers, biophysics, medical equipment, especially cardiology diagnostics device, developers, educators, nurses, healthcare decision-makers, people with cardiovascular diseases, cardiology and engineering universities and schools, state and private clinics. Cardiometry is aimed to provide a wide forum for exchange of information and public discussion on above scientific issues for the mentioned experts.