Persistent Hyper IgA as a Marker of Immune Deficiency: A Case Report

IF 3 Q3 IMMUNOLOGY

Antibodies Pub Date : 2022-04-25 DOI:10.3390/antib11020030

R. Hopp, H. Niebur

引用次数: 1

Abstract

An elevated IgA level obtained in a 10-year-old male a year after an episode of pneumococcal sepsis led to the discovery of a broad-based IgG-specific antibody deficiency syndrome. The specifics of the case and pertinent literature are presented, including a discussion of the hyper-IgD syndrome. An elevated IgA, greater than two standard deviations above the expected age range should prompt a complete workup for selective antibody deficiency syndrome and adds an additional associated marker of an indolent hyper-IgD syndrome in a different clinical circumstance, although the lack of antibody response to vaccines is atypical of the hyper-IgD syndrome.

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持续高IgA作为免疫缺陷的标志:1例报告

一名10岁男性在肺炎球菌败血症发作一年后IgA水平升高，导致发现广泛的igg特异性抗体缺乏综合征。具体的情况和相关文献提出，包括高igd综合征的讨论。IgA升高，高于预期年龄范围大于两个标准差，应提示对选择性抗体缺乏综合征进行全面检查，并在不同的临床情况下增加惰性高igd综合征的额外相关标记，尽管缺乏对疫苗的抗体反应是非典型的高igd综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibodies IMMUNOLOGY-

CiteScore

7.10

自引率

6.40%

发文量

审稿时长

11 weeks

期刊介绍： Antibodies (ISSN 2073-4468), an international, peer-reviewed open access journal which provides an advanced forum for studies related to antibodies and antigens. It publishes reviews, research articles, communications and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided. Electronic files or software regarding the full details of the calculation and experimental procedure - if unable to be published in a normal way - can be deposited as supplementary material. This journal covers all topics related to antibodies and antigens, topics of interest include (but are not limited to): antibody-producing cells (including B cells), antibody structure and function, antibody-antigen interactions, Fc receptors, antibody manufacturing antibody engineering, antibody therapy, immunoassays, antibody diagnosis, tissue antigens, exogenous antigens, endogenous antigens, autoantigens, monoclonal antibodies, natural antibodies, humoral immune responses, immunoregulatory molecules.