Clinical characteristics and prognosis of multiple primary colorectal carcinoma

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-03-28 DOI:10.3760/CMA.J.CN115355-20190718-00314

Ziwei Xu, Yifei Feng, Yong Wang, Junwei Tang, Zan Fu

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Abstract

Objective To explore the clinical characteristics and prognosis of multiple primary colorectal carcinoma. Methods The clinical data of 42 cases of colorectal cancer admitted to the First Affiliated Hospital of Nanjing Medical University between January 2013 and December 2018 were retrospectively analyzed. The clinicopathological features, diagnosis, treatment and prognosis were summarized. Results There were 42 patients with multiple primary colorectal carcinoma, accounting for 1.20% (42/3 499) of all colorectal carcinoma patients in the same period. The main pathological type was adenocarcinoma. Among them, 32 cases were synchronous multiple primary carcinoma. And the age ranged 38-86 years old, and the median age was 66 years old. A total of 73 colorectal cancer lesions were detected, mostly located in the proximal colon, sigmoid colon and rectum. A total of 527 lymph nodes were detected, and the positive rate was 1.9% (10). Patients with positive lymph nodes accounted for 37.5% (12/32), including 27 cases of multiple primary carcinoma, 3 cases of triple primary carcinoma, 2 cases of five primary carcinoma. The 1-year and 3-year overall survival rates were 83.75% and 74.38%, respectively. There were 10 cases of metachronous multiple primary carcinoma. Patients were aged 33-86 years old. The first cancer was mostly located in the rectum and sigmoid colon, and the second cancer was mostly located in the ascending colon area. A total of 276 lymph nodes were detected, and the positive rate was 12.3% (34). The 1-year and 3-year overall survival rates were 100.00% and 66.67%, respectively. Conclusions Multiple primary colorectal cancer is not rare clinically and its distribution shows a certain regularity. More attention should be paid to improve the early diagnosis rate. Early operation is needed to improve the survival rate of patients. Key words: Colorectal neoplasms; Neoplasms, multiple primary; Clinical characteristics; Prognosis

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多发原发结直肠癌的临床特点及预后

目的探讨多发原发结直肠癌的临床特点及预后。方法回顾性分析2013年1月至2018年12月南京医科大学第一附属医院收治的42例结直肠癌患者的临床资料。总结其临床病理特点、诊断、治疗及预后。结果多发原发结直肠癌42例，占同期结直肠癌患者的1.20%(42/ 499)。主要病理类型为腺癌。其中32例为同步多发原发癌。年龄38 ~ 86岁，中位年龄66岁。共检出结直肠癌病变73例，多位于结肠近端、乙状结肠和直肠。共检出淋巴结527例，阳性率1.9%(10)。淋巴结阳性患者占37.5%(12/32)，其中多原发癌27例，三原发癌3例，五原发癌2例。1年和3年总生存率分别为83.75%和74.38%。异时多发原发癌10例。患者年龄33-86岁。第一种癌多位于直肠和乙状结肠，第二种癌多位于升结肠区。共检出淋巴结276例，阳性率为12.3%(34例)。1年和3年总生存率分别为100.00%和66.67%。结论多发原发结直肠癌在临床上并不少见，其分布有一定的规律性。应重视提高早期诊断率。早期手术治疗可提高患者的生存率。关键词:结直肠肿瘤;肿瘤，多发原发;临床特点;预后

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.