The Efficacy and Safety of a Low-Fluence 1064 nm Picosecond ND-YAG Laser Compared with Those of a Low-Fluence Photoacoustic Therapy Pulsed (PTP) Mode 1064 nm Q-Switched ND-YAG Laser for Treatment of Melasma: A Prospective Split-Face Study

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2023-06-26 DOI:10.1155/2023/5961152

S. Y. Lee, H. Kim, J. Park, Jin Cheol Kim, C. Park, H. Kim, B. Chung

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引用次数: 1

Abstract

Melasma is a challenging pigmentation disorder to treat, and although low-fluence 1064 nm picosecond ND-YAG lasers have shown potential for treating benign pigmented disorders, data on the use of this laser for melasma treatment are currently insufficient. In this prospective split-face study, twenty-four patients with melasma on the face were enrolled and randomly assigned to receive treatment on one side of the face either with a low-fluence 1064 nm picosecond ND-YAG laser or with a low-fluence PTP mode 1064 nm Q-switched ND-YAG laser. Laser treatment was performed 5 times at intervals of 2 weeks, with evaluation conducted before each treatment and 2 months after the completion of 5 treatments. Clinical pictures using a standardized, digital photographic system and dermoscopy were taken on each day of the visit. The modified melasma area severity index (mMASI), melanin index (MI), dermoscopic scores of the pigmentary and vascular elements in melasma, pain during laser treatment, and patient satisfaction score were recorded. Twenty-one participants completed the study, and from week 2 in both groups, a significant decrease in mMASI and MI were confirmed. Although no statistically significant difference was observed, the decrease in mMASI and MI were greater in the 1064 nm picosecond ND-YAG laser group than in the 1064 nm Q-switched ND-YAG laser group. The 1064 nm picosecond ND-YAG laser group showed significant improvement in the pseudoreticular network and globular pattern of dermoscopic features between week 0 and week 16, while significant improvement in the globular pattern was shown in the 1064 nm Q-switched ND-YAG laser group. No significant difference was observed between the two groups in terms of the patient satisfaction score and pain during laser treatments. Notably, no adverse events were observed in either group. In conclusion, our study demonstrated that a low-fluence 1064 nm picosecond ND-YAG laser is as effective and safe in the treatment of melasma as a low-fluence PTP mode 1064 nm Q-switched ND-YAG laser.

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低通量1064 nm皮秒ND-YAG激光器与低通量光声治疗脉冲(PTP)模式1064 nm调q ND-YAG激光器治疗黄褐斑的疗效和安全性比较:一项前瞻性裂面研究

黄褐斑是一种具有挑战性的色素沉着疾病的治疗，尽管低能量1064 nm皮秒ND-YAG激光已经显示出治疗良性色素沉着疾病的潜力，但目前使用这种激光治疗黄褐斑的数据不足。在这项前瞻性面部分裂研究中，24名面部黄褐斑患者被招募并随机分配接受一侧面部低通量1064 nm皮秒ND-YAG激光治疗或低通量PTP模式1064 nm调q ND-YAG激光治疗。激光治疗5次，间隔2周，每次治疗前及5次治疗结束后2个月进行评估。临床图片使用标准化的数码摄影系统和皮肤镜在每天的访问。记录改良黄褐斑面积严重程度指数(mMASI)、黑色素指数(MI)、皮肤镜下黄褐斑色素和血管成分评分、激光治疗时疼痛、患者满意度评分。21名参与者完成了研究，从第2周开始，两组的mMASI和MI均有显著下降。虽然无统计学差异，但1064 nm皮秒ND-YAG激光组mMASI和MI的下降幅度大于1064 nm调q ND-YAG激光组。在第0周至第16周，1064 nm皮秒ND-YAG激光组皮肤镜特征的假网状网络和球状模式有显著改善，而1064 nm调q ND-YAG激光组的球状模式有显著改善。两组患者在激光治疗期间的满意度评分和疼痛无显著差异。值得注意的是，两组均未观察到不良事件。总之，我们的研究表明，低通量1064 nm皮秒ND-YAG激光治疗黄褐斑与低通量PTP模式1064 nm调q ND-YAG激光治疗黄褐斑一样有效和安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.