Related pathological factors in treatment and prognosis of diffuse large B-cell lymphoma

国际输血及血液学杂志 Pub Date : 2019-05-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.03.001

Zhe Wang

引用次数: 0

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin′s lymphoma (NHL), DLBCL comprised about 1/3 of all NHL cases. DLBCL is a kind of highly aggressive neoplasm. Precise diagnosis of DLBCL was only made by combination of morphological, immunophenotype and clinical manifestations evidence. In recent decade, molecular study of DLBCL progresses very rapidly, the new advances promoted the prognosis prediction and treatment strategy of DLBCL. In this paper, we will focus on the important pathological issues for the treatment and prognosis prediction of DLBCL, for examples, pathologic subtype, morphology, cell of origin, genetic alteration, immunophenotype and tumor immune micro-enviroment. Key words: Lymphoma, B-cell; Lymphoma, large B-cell, diffuse; Tumor microenviroment; Genetic alteration; Cell of origin

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弥漫性大B细胞淋巴瘤治疗及预后的相关病理因素

弥漫性大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤(NHL)最常见的亚型，约占所有NHL病例的1/3。DLBCL是一种侵袭性很强的肿瘤。DLBCL的准确诊断需要结合形态学、免疫表型和临床表现。近十年来，DLBCL的分子研究进展迅速，新的进展促进了DLBCL的预后预测和治疗策略。本文将重点讨论DLBCL的病理亚型、形态、细胞起源、基因改变、免疫表型和肿瘤免疫微环境等对DLBCL治疗和预后预测的重要病理问题。关键词:淋巴瘤;b细胞;淋巴瘤，大b细胞，弥漫性;肿瘤microenviroment;基因改造;细胞来源

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.