The comparative effect of lidocaine-remifentanil intravenous infusion and gargle on hemodynamic responses and sore throat and cough after endotracheal extubation: A randomized clinical trial

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
M. Shabani, H. Modir, F. Barsari
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引用次数: 0

Abstract

Purpose: The present evidence-based clinical study addressed the therapeutic effectiveness of lidocaine-remifentanil intravenous infusion versus gargle on attenuation of hemodynamic responses and prevention of sore throat and cough after endotracheal extubation. Materials and Methods: In a double-blind clinical trial whereby 76 cases receiving endotracheal intubation under general anesthesia were classified into two intervention groups being treated with lidocaine-remifentanil mixture administered by either intravenous infusion or gargle using balanced block randomization. Hemodynamic parameters including heart rate and blood pressure during surgery and in recovery every 15 min and respiratory symptoms such as cough, hoarseness, and sore throat during recovery and at certain postoperative time points of 2, 4, 8, 12, and 24 h were gathered. Pain score was measured by a Visual Analog Scale. Statistical analysis was conducted using the software SPSS v22 by Chi-square and independent t-test. Results: No statistically significant observed intergroup in terms of oxygen saturation, heart rate, mean blood pressure, need for analgesic medication, duration of surgery, and the incidence of cough and hoarseness (P > 0.05), but not in pain score in recovery and eight postoperative hours. While the intergroup difference was found at other times, the intravenous infusion group was associated with less pain score, compared to the gargling group (P > 0.05). Conclusion: A reduction in sore throat observed in subjects receiving an intravenous infusion compared to those receiving the gargling intervention during recovery and 8 h after surgery. We have convincing evidence to support the superiority of intravenous therapy comprising of lidocaine and remifentanil; however, larger sample size is needed to establish whether or not the interventions are effective.
利多卡因瑞芬太尼静脉滴注与漱口对气管插管后血液动力学反应及喉咙痛和咳嗽的比较:一项随机临床试验
目的:本循证临床研究探讨了瑞芬太尼静脉输注利多卡因与漱口利多卡因在减轻血液动力学反应和预防气管内拔管后喉咙痛和咳嗽方面的疗效。材料和方法:在一项双盲临床试验中,76例在全麻下接受气管插管的患者被分为两个干预组,分别用利多卡因瑞芬太尼混合物进行静脉输注或漱口,采用平衡分组随机化。收集血液动力学参数,包括手术期间和每15分钟恢复一次的心率和血压,以及恢复期间和术后2、4、8、12和24小时的某些时间点的咳嗽、声音嘶哑和喉咙痛等呼吸道症状。疼痛评分采用视觉模拟量表进行测量。统计分析采用SPSS v22软件卡方检验和独立t检验。结果:组间氧饱和度、心率、平均血压、镇痛药物需求、手术时间、咳嗽和声音嘶哑的发生率均无统计学意义(P>0.05),但恢复期和术后8小时的疼痛评分无统计学意义。虽然在其他时间发现了组间差异,但与漱口组相比,静脉输液组的疼痛评分较低(P>0.05)。我们有令人信服的证据支持利多卡因和瑞芬太尼静脉注射治疗的优越性;然而,需要更大的样本量来确定干预措施是否有效。
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来源期刊
Journal of Head & Neck Physicians and Surgeons
Journal of Head & Neck Physicians and Surgeons MEDICINE, GENERAL & INTERNAL-
CiteScore
0.30
自引率
0.00%
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0
审稿时长
15 weeks
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