Effect of Lactoferrin on Paraoxonase Activity, Some Acute Phase Proteins and Oxidant/Antioxidant System

M. Ozturkler, O. Atakisi
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Abstract

Lactoferrin is a member of the high affinity to glycoprotein family of transferrin for iron and plays a role in natural immunity as well as antibacterial, antifungal, antiviral, antiparasitic, antioxidant, anticancer, antiinflammatory, bone health and immunomodulation. The aim this study was to investigate of the acute effect of lactoferrin on paraoxonase activity, oxidant/antioxidant system and total protein, albumin and globulin. This study was carried out on 6-month Sprague Dawley rats in a total number of 20 subjects. Paraoxonase activity, total antioxidant capacity (TAC), total oxidant capacity (TOC), total protein, albumin and globulin levels were measured through the spectrophotometer. When the lactoferrin group was compared with the control group, it was found that TAC levels were statistically higher (P<0.05), TOC levels were statistically lower (P<0.01) and paraoxonase activity was statistically higher (P<0.05). There was no difference in total protein and globulin levels in the lactoferrin group compared to the control group. As a result, acute lactoferrin administration may play an important role in the regulation of antioxidant balance by increasing paraoxonase activity and decreasing the level of reactive oxygen species.
乳铁蛋白对对对氧磷酶活性、某些急性期蛋白质及氧化/抗氧化系统的影响
乳铁蛋白是铁对转铁蛋白糖蛋白家族的高亲和力成员,在自然免疫以及抗菌、抗真菌、抗病毒、抗寄生虫、抗氧化、抗癌、抗炎、骨骼健康和免疫调节中发挥作用。本研究的目的是研究乳铁蛋白对对对氧磷酶活性、氧化/抗氧化系统以及总蛋白、白蛋白和球蛋白的急性影响。本研究在总共20名受试者中对6个月大的Sprague-Dawley大鼠进行。用分光光度计测定对氧磷酶活性、总抗氧化能力(TAC)、总氧化能力(TOC)、总蛋白、白蛋白和球蛋白水平。乳铁蛋白组与对照组比较,TAC水平显著升高(P<0.05),TOC水平显著降低(P<0.01),对氧磷酶活性显著升高(P<0.01)。乳铁蛋白组总蛋白和球蛋白水平与对照组相比无差异。因此,急性乳铁蛋白给药可能通过提高对氧磷酶活性和降低活性氧水平,在调节抗氧化平衡中发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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